Expression of CD15 in the bulbar conjunctiva among T2DM patients with ocular surface damage.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Tetiana Zhmud, Stefano Barabino, Galyna Drozhzhyna
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引用次数: 0

Abstract

BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, which induces ocular surface damage due to low-grade inflammation.AimTo detect and evaluate relative epithelial expression of CD15 in bulbar conjunctiva among patients with and without T2DM based on results of conjunctival impression cytology (CIC), in order to study its role in conjunctival parainflammation related to T2DM.Materials and methodsWe conducted a prospective observational study from March 2023 to December 2023. Forty-eight T2DM patients (96 eyes) were enrolled into a study group. The control group included forty (80 eyes) age- and sex-matched healthy volunteers. All patients underwent conjunctival impression cytology (CIC) and expression of CD15 in bulbar conjunctiva.ResultsExpression of CD15 was detected on epithelial cells in 95% of samples in the study group and 15% of the controls, is statistically significant (p = 0.0000). Mean expression of CD was at 0.96 ± 1.28%, and it was significantly different from the study group with the same Nelson's grade - 3.81 ± 1.48% (p = 0.0351). CD 15 values were significantly higher between Nelson II and III in the study group (3.81 ± 1.48; 7.72 ± 1.65; p = 0.0000, respectively).ConclusionsThe research shows that T2DM patients are prone to increased epithelial expression of CD 15 compared to healthy controls. Relative expression of CD15 may be utilized as a potential marker to evaluate topical treatment outcomes of ocular surface damage in T2DM.

T2DM伴眼表损伤患者球结膜中CD15的表达。
背景2型糖尿病(T2DM)是一种慢性代谢性疾病,由低度炎症引起眼表损伤。目的通过结膜印象细胞学(CIC)检测和评价T2DM患者和非T2DM患者球结膜中CD15上皮细胞的相对表达,探讨其在T2DM相关结膜副炎症中的作用。材料与方法我们于2023年3月至2023年12月进行了一项前瞻性观察研究。48例T2DM患者(96只眼)被纳入研究组。对照组包括40名(80只眼睛)年龄和性别匹配的健康志愿者。所有患者均行结膜印象细胞学检查(CIC)和球结膜CD15的表达。结果研究组95%的样本和对照组15%的样本的上皮细胞上检测到CD15的表达,差异有统计学意义(p = 0.0000)。CD平均表达量为0.96±1.28%,与Nelson分级相同的研究组(3.81±1.48%)差异有统计学意义(p = 0.0351)。Nelson II和III组的cd15值显著高于对照组(3.81±1.48;7.72±1.65;P = 0.0000)。结论T2DM患者与健康对照组相比,cd15的上皮表达增加。CD15的相对表达可作为评价T2DM患者眼表损伤局部治疗效果的潜在指标。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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