Expression of CD15 in the bulbar conjunctiva among T2DM patients with ocular surface damage.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Tetiana Zhmud, Stefano Barabino, Galyna Drozhzhyna
{"title":"Expression of CD15 in the bulbar conjunctiva among T2DM patients with ocular surface damage.","authors":"Tetiana Zhmud, Stefano Barabino, Galyna Drozhzhyna","doi":"10.1177/11206721251327642","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, which induces ocular surface damage due to low-grade inflammation.AimTo detect and evaluate relative epithelial expression of CD15 in bulbar conjunctiva among patients with and without T2DM based on results of conjunctival impression cytology (CIC), in order to study its role in conjunctival parainflammation related to T2DM.Materials and methodsWe conducted a prospective observational study from March 2023 to December 2023. Forty-eight T2DM patients (96 eyes) were enrolled into a study group. The control group included forty (80 eyes) age- and sex-matched healthy volunteers. All patients underwent conjunctival impression cytology (CIC) and expression of CD15 in bulbar conjunctiva.ResultsExpression of CD15 was detected on epithelial cells in 95% of samples in the study group and 15% of the controls, is statistically significant (<i>p</i> = 0.0000). Mean expression of CD was at 0.96 ± 1.28%, and it was significantly different from the study group with the same Nelson's grade - 3.81 ± 1.48% (<i>p</i> = 0.0351). CD 15 values were significantly higher between Nelson II and III in the study group (3.81 ± 1.48; 7.72 ± 1.65; <i>p</i> = 0.0000, respectively).ConclusionsThe research shows that T2DM patients are prone to increased epithelial expression of CD 15 compared to healthy controls. Relative expression of CD15 may be utilized as a potential marker to evaluate topical treatment outcomes of ocular surface damage in T2DM.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251327642"},"PeriodicalIF":1.4000,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/11206721251327642","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, which induces ocular surface damage due to low-grade inflammation.AimTo detect and evaluate relative epithelial expression of CD15 in bulbar conjunctiva among patients with and without T2DM based on results of conjunctival impression cytology (CIC), in order to study its role in conjunctival parainflammation related to T2DM.Materials and methodsWe conducted a prospective observational study from March 2023 to December 2023. Forty-eight T2DM patients (96 eyes) were enrolled into a study group. The control group included forty (80 eyes) age- and sex-matched healthy volunteers. All patients underwent conjunctival impression cytology (CIC) and expression of CD15 in bulbar conjunctiva.ResultsExpression of CD15 was detected on epithelial cells in 95% of samples in the study group and 15% of the controls, is statistically significant (p = 0.0000). Mean expression of CD was at 0.96 ± 1.28%, and it was significantly different from the study group with the same Nelson's grade - 3.81 ± 1.48% (p = 0.0351). CD 15 values were significantly higher between Nelson II and III in the study group (3.81 ± 1.48; 7.72 ± 1.65; p = 0.0000, respectively).ConclusionsThe research shows that T2DM patients are prone to increased epithelial expression of CD 15 compared to healthy controls. Relative expression of CD15 may be utilized as a potential marker to evaluate topical treatment outcomes of ocular surface damage in T2DM.

求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信