Review on the Function, Substrate Affinity, and Potential Application of Bile Salt Hydrolase Originated from Probiotic Strains of Lactobacillus, Bifidobacterium, and Enterococcus.

IF 4.2 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Science of Animal Resources Pub Date : 2025-03-01 DOI:10.5851/kosfa.2025.e1

Mo Hyeon Kang, Arxel G Elnar, Geun-Bae Kim

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引用次数: 0

Abstract

Bile salt hydrolase (BSH: EC.3.5.1.24) has been used as a biomarker for probiotics for an extended period. It is mostly present in the gut environment of vertebrates. Additionally, it influences the viability of probiotics. This biomarker is considered a promising nutritional supplement due to its unique ability to effectively address elevated blood cholesterol levels, a common issue in modern society. However, the commercialization of BSH has been limited by an incomplete understanding of the intestinal microbiota and the function of BSH. Hence, in this review, we aim to reveal the current advancements in BSH research and outline the necessary areas of investigation for future studies. The review highlights key findings related to the substrate affinity of BSH in probiotic bacteria and its BSH gene phylogeny that have been researched until today, suggesting further research regarding the differences in multiple BSH genes and corresponding differences in BSH affinity.

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胆盐水解酶（BSH：EC.3.5.1.24）长期以来一直被用作益生菌的生物标志物。它主要存在于脊椎动物的肠道环境中。此外，它还会影响益生菌的活力。这种生物标志物被认为是一种很有前景的营养补充剂，因为它具有有效解决血液胆固醇水平升高这一现代社会常见问题的独特能力。然而，由于对肠道微生物群和 BSH 功能的了解不全面，BSH 的商业化一直受到限制。因此，在本综述中，我们旨在揭示目前 BSH 研究的进展，并概述未来研究的必要调查领域。综述重点介绍了益生菌中 BSH 的底物亲和力及其 BSH 基因系统发育的相关研究成果，并建议进一步研究多个 BSH 基因的差异以及 BSH 亲和力的相应差异。

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来源期刊

Food Science of Animal Resources Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

6.70

自引率

6.70%

发文量

期刊介绍： Food Science of Animal Resources (Food Sci. Anim. Resour.) is an international, peer-reviewed journal publishing original research and review articles on scientific and technological aspects of chemistry, biotechnology, processing, engineering, and microbiology of meat, egg, dairy, and edible insect/worm products.