Association of Metabolic Score for Visceral Fat (METS-VF) with Gout Risk in Patients with Hypertension and Hyperuricemia: A Multicenter Study Based on the Chinese Population.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Liwei Ji, Wencai Jiang, Jinglin Huang, Yan Xu, Li Zhou, Zeng Zhao, Chunling Jiang
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引用次数: 0

Abstract

Background: Gout, a rheumatic disease precipitated by hyperuricemia, has become a global health concern due to its increasing prevalence, especially in China. Hyperuricemia and hypertension are significant risk factors for gout, and their coexistence amplifies this risk. Visceral adipose tissue (VAT) plays a crucial role in cardiometabolic diseases, and the metabolic score for visceral fat (METS-VF) is a non-invasive tool for estimating VAT and predicting cardiometabolic risk.

Methods: We conducted a multicenter cross-sectional study involving 8877 patients with hypertension and hyperuricemia from three Chinese medical centers between March 2021 and September 2024. We calculated the METS-VF and other obesity indices and analyzed their associations with gout risk using logistic regression models. The predictive performance of these indices was evaluated using receiver operating characteristic (ROC) curve analysis and clinical decision curve analysis (DCA).

Results: The METS-VF demonstrated a significant positive association with gout risk, independent of traditional risk factors. Each 1-standard deviation increase in the METS-VF was associated with an 82% higher odds of gout (OR=1.82, 95% CI: 1.62 to 2.03). The METS-VF outperformed other obesity indices in predicting gout risk, with a higher area under the ROC curve (AUC) value. DCA indicated that the METS-VF provided a significant net benefit across a wide range of threshold probabilities for predicting gout risk in both genders.

Conclusion: The METS-VF's robust association with gout risk in our multicenter study, independent of conventional risk factors, positions it as a potent predictor for gout. Further investigation is warranted to clarify the underlying mechanisms and the long-term predictive validity of the METS-VF across diverse populations.

高血压和高尿酸血症患者内脏脂肪代谢评分(METS-VF)与痛风风险的关联:一项基于中国人群的多中心研究
背景:痛风是一种由高尿酸血症引起的风湿病,由于其发病率的增加而成为全球关注的健康问题,特别是在中国。高尿酸血症和高血压是痛风的重要危险因素,它们的共存放大了这种风险。内脏脂肪组织(VAT)在心脏代谢疾病中起着至关重要的作用,而内脏脂肪代谢评分(METS-VF)是估计VAT和预测心脏代谢风险的无创工具。方法:我们在2021年3月至2024年9月期间对来自中国三个医疗中心的8877例高血压和高尿酸血症患者进行了多中心横断面研究。我们计算了met - vf和其他肥胖指数,并使用logistic回归模型分析了它们与痛风风险的关系。采用受试者工作特征(ROC)曲线分析和临床决策曲线分析(DCA)评价这些指标的预测性能。结果:met - vf与痛风风险呈显著正相关,独立于传统风险因素。met - vf每增加1个标准差,痛风发生率增加82% (OR=1.82, 95% CI: 1.62 ~ 2.03)。met - vf在预测痛风风险方面优于其他肥胖指标,其ROC曲线下面积(AUC)值更高。DCA表明,met - vf在广泛的阈值概率范围内为预测男女痛风风险提供了显著的净收益。结论:在我们的多中心研究中,met - vf与痛风风险的相关性很强,独立于传统的风险因素,将其定位为痛风的有效预测因子。有必要进一步研究以阐明METS-VF在不同人群中的潜在机制和长期预测有效性。
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来源期刊
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
5.90
自引率
6.10%
发文量
431
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.
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