No change in interictal plasma and salivary CGRP levels in individuals with vestibular migraine corresponding to episodic migraine.

IF 5 2区 医学 Q1 CLINICAL NEUROLOGY
Cephalalgia Pub Date : 2025-03-01 Epub Date: 2025-03-17 DOI:10.1177/03331024251322418
Yutong Bai, Min Kyung Chu, Jin-Ju Kang, Juhee Chae, Marianne Dieterich, Sun-Young Oh
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引用次数: 0

Abstract

BackgroundFew studies have examined plasma calcitonin gene-related peptide (CGRP) levels in individuals with vestibular migraine (VM), with inconsistent findings. Additionally, salivary CGRP levels in VM have not been reported.MethodsInterictal plasma and salivary CGRP levels were measured using an enzyme-linked immunosorbent assay in participants with VM corresponding to episodic migraine (VM, n = 81), chronic migraine without vestibular symptoms (CM, n = 73) and healthy controls (HC, n = 59).ResultsPlasma CGRP levels in VM with episodic migraine participants were significantly lower than those in participants with CM (median = 37.1 pg/mL, interquartile range (IQR) = 22.4-60.4 pg/mL vs. median = 74.6 pg/mL, IQR  = 49.6-101.6 pg/mL; p < 0.001) but did not significantly differ from levels in HC. Similarly, salivary CGRP levels were also significantly lower in VM compared to CM (median = 54.5 pg/mL, IQR = 37.0-83.4 pg/mL vs. median = 72.0 pg/mL, IQR  = 56.5-96.2 pg/mL; p = 0.036), with no significant difference observed between VM and HC. Receiver operating characteristic analysis showed that plasma CGRP levels effectively differentiated CM from VM corresponding to episodic migraine, achieving an area under the curve of 0.88. No significant correlations were found between plasma or salivary CGRP levels and clinical features of CM and VM.ConclusionsInterictal plasma and salivary CGRP levels are unlikely to serve a biomarkers for VM.

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来源期刊
Cephalalgia
Cephalalgia 医学-临床神经学
CiteScore
10.10
自引率
6.10%
发文量
108
审稿时长
4-8 weeks
期刊介绍: Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.
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