Cellular and Molecular Mechanisms of Phytochemicals Against Inflammation-Associated Diseases and Viral Infection.

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Zhaodi Zheng, Junying Gao, Yubing Ma, Xitan Hou
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Abstract

Inflammation-associated diseases have become widespread and pose a significant threat to human health, and the therapeutic methods for diverse diseases are inadequate due to the undesirable effects of synthetic ingredients. Recently, more and more evidence indicated that phytochemicals, plant secondary metabolites, have numerous therapeutic functions against human diseases via affecting a variety of mechanisms with their distinct advantages of high efficiency and low toxicity. Here, we highlight the mechanisms of phytochemicals to hinder inflammation-associated diseases (including Inflammatory diseases, cardiovascular diseases, metabolic syndrome, neurological disorders, skin diseases, respiratory diseases, kidney diseases, gastrointestinal diseases, retinal diseases, viral infections) by regulating the crosstalk among various signal cascades (including MicroRNAs, SIRT1, DNMTs, NF-κB, NLRP3, TGF-β, the Gasdermin-mediated pyroptosis pathway), which can be considered as a novel and potential therapeutic strategy. Furthermore, phytochemicals could prevent virus infection by disturbing different targets in the virus replication cycle. However, natural plants have shown limited bioavailability due to their low water solubility, the use of adjuvants such as liposomal phytochemicals, phytochemical nanoparticles and phytochemicals-phospholipid complex promote their bioavailability to exhibit beneficial effects against various diseases. The purpose of this review is to explore the molecular mechanisms and promising applications of phytochemicals in the fields of inflammation-associated diseases and virus infection to provide some direction.

植物化学物质抗炎症相关疾病和病毒感染的细胞和分子机制。
炎症相关疾病已经广泛存在并对人类健康构成了重大威胁,但由于合成成分的不良影响,各种疾病的治疗方法不足。近年来,越来越多的证据表明,植物化学物质作为植物次生代谢产物,通过多种作用机制对人类疾病具有多种治疗作用,具有高效、低毒的明显优势。在这里,我们重点介绍了植物化学物质通过调节各种信号级联(包括microrna、SIRT1、dnmt、NF-κB、NLRP3、TGF-β、气胶蛋白介导的焦亡通路)之间的串扰,抑制炎症相关疾病(包括炎症性疾病、心血管疾病、代谢综合征、神经系统疾病、皮肤病、呼吸系统疾病、肾脏疾病、胃肠道疾病、视网膜疾病、病毒感染)的机制。这可以被认为是一种新的和潜在的治疗策略。此外,植物化学物质可以通过干扰病毒复制周期中的不同靶点来预防病毒感染。然而,由于天然植物水溶性较低,其生物利用度有限,因此使用脂质体植物化学物质、植物化学纳米颗粒和植物化学物质-磷脂复合物等佐剂可促进其生物利用度,从而对各种疾病发挥有益作用。本文旨在探讨植物化学物质在炎症相关疾病和病毒感染领域的分子机制及其应用前景,为今后研究提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Biology International
Cell Biology International 生物-细胞生物学
CiteScore
7.60
自引率
0.00%
发文量
208
审稿时长
1 months
期刊介绍: Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect. These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
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