Use of Bivalirudin for a Pediatric Patient with Two Mechanical Heart Valves: a case report.

IF 0.9 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-03-17 DOI:10.1017/S1047951125001283
Joshua W Branstetter, John Wagner, Hania Zaki, Gary Woods, Heather Viamonte
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引用次数: 0

Abstract

Despite advances in the development of systemic anticoagulants, there remain few agents approved for utilisation in patients with mechanical heart valves. Currently, recommendations for periprocedural and long-term anticoagulation in mechanical heart valves include unfractionated heparin or vitamin K antagonists, and there are some reports for off-label use of low-molecular-weight heparins. Emerging data on parenteral direct thrombin inhibitors, such as bivalirudin, have led to increased utilisation in both extracorporeal membrane oxygenation and ventricular assist devices. We present the case of a paediatric patient with rheumatic heart disease who had significant bleeding on unfractionated heparin who successfully received prolonged bivalirudin therapy in the setting of mechanical aortic and mitral heart valves.

比伐鲁定用于双机械心脏瓣膜患儿一例报告。
尽管全身抗凝剂的发展取得了进展,但仍有少数药物被批准用于机械心脏瓣膜患者。目前,推荐的机械心脏瓣膜围手术期和长期抗凝治疗包括未分级肝素或维生素K拮抗剂,也有一些低分子肝素在说明书外使用的报道。关于肠外直接凝血酶抑制剂的新数据,如比伐鲁定,导致体外膜氧合和心室辅助装置的使用率增加。我们提出了一例患有风湿性心脏病的儿科患者,他在使用未分离肝素时出血严重,在机械主动脉瓣和二尖瓣的情况下成功地接受了延长的比伐鲁定治疗。
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来源期刊
Cardiology in the Young
Cardiology in the Young 医学-小儿科
CiteScore
1.70
自引率
10.00%
发文量
715
审稿时长
4-8 weeks
期刊介绍: Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. By design, the journal is international and multidisciplinary in its approach, and members of the editorial board take an active role in the its mission, helping to make it the essential journal in paediatric cardiology. All aspects of paediatric cardiology are covered within the journal. The content includes original articles, brief reports, editorials, reviews, and papers devoted to continuing professional development.
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