Factors influencing disease-free survival after radical endometrial cancer surgery: an analysis of the competitive risk prediction mode.

IF 1.7 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
American journal of translational research Pub Date : 2025-02-15 eCollection Date: 2025-01-01 DOI:10.62347/BRVI1759
Xing Cao, Jianhui Fang, Yanling Wei, Shanbin Liang
{"title":"Factors influencing disease-free survival after radical endometrial cancer surgery: an analysis of the competitive risk prediction mode.","authors":"Xing Cao, Jianhui Fang, Yanling Wei, Shanbin Liang","doi":"10.62347/BRVI1759","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the factors influencing disease-free survival (DFS) of patients with endometrial cancer after surgery and construct a competing risk prediction model.</p><p><strong>Methods: </strong>Clinical data of endometrial cancer patients admitted to the First People's Hospital of Qinzhou City from October 2015 to January 2021 were retrospectively analyzed. A total of 280 patients were included, randomly split into a training set (202 cases) and a validation set (78 cases) in a 7:3 ratio using RStudio software. A Fine-Gray competing risk model was applied to the training set to identify factors associated with reduced postoperative DFS. Based on these factors, a prognostic prediction model was established, and a nomogram was created. The model's performance was evaluated using the concordance index (C-index), receiver operating characteristic (ROC) curve and calibration curve.</p><p><strong>Results: </strong>Multifactorial analysis revealed that age, body mass index (BMI), diabetes mellitus, depth of basal infiltration, cancer antigen 125 (CA125), and human epididymis protein 4 (HE4) were the factors influencing postoperative DFS in endometrial cancer patients (P < 0.05). In the training set, the constructed model showed AUC values of 0.773, 0.802, and 0.858 in predicting 1-, 2-, and 4-year DFS, respectively. In the validation set, the AUC values were 0.923, 0.829, and 0.746, respectively. The C-index in the training set and the validation set was 0.786 and 0.515, respectively. The calibration curve indicated that the predicted cumulative survival probabilities closely matched the actual probabilities in both the training and validation sets.</p><p><strong>Conclusions: </strong>The Fine-Gray competing risk prediction model is effective in identifying factors influencing postoperative DFS in patients with endometrial cancer. The nomograms derived from this model have a strong predictive value and can help clinicians in identifying high-risk patients and tailoring individualized interventions.</p>","PeriodicalId":7731,"journal":{"name":"American journal of translational research","volume":"17 2","pages":"1265-1276"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909515/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of translational research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/BRVI1759","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To investigate the factors influencing disease-free survival (DFS) of patients with endometrial cancer after surgery and construct a competing risk prediction model.

Methods: Clinical data of endometrial cancer patients admitted to the First People's Hospital of Qinzhou City from October 2015 to January 2021 were retrospectively analyzed. A total of 280 patients were included, randomly split into a training set (202 cases) and a validation set (78 cases) in a 7:3 ratio using RStudio software. A Fine-Gray competing risk model was applied to the training set to identify factors associated with reduced postoperative DFS. Based on these factors, a prognostic prediction model was established, and a nomogram was created. The model's performance was evaluated using the concordance index (C-index), receiver operating characteristic (ROC) curve and calibration curve.

Results: Multifactorial analysis revealed that age, body mass index (BMI), diabetes mellitus, depth of basal infiltration, cancer antigen 125 (CA125), and human epididymis protein 4 (HE4) were the factors influencing postoperative DFS in endometrial cancer patients (P < 0.05). In the training set, the constructed model showed AUC values of 0.773, 0.802, and 0.858 in predicting 1-, 2-, and 4-year DFS, respectively. In the validation set, the AUC values were 0.923, 0.829, and 0.746, respectively. The C-index in the training set and the validation set was 0.786 and 0.515, respectively. The calibration curve indicated that the predicted cumulative survival probabilities closely matched the actual probabilities in both the training and validation sets.

Conclusions: The Fine-Gray competing risk prediction model is effective in identifying factors influencing postoperative DFS in patients with endometrial cancer. The nomograms derived from this model have a strong predictive value and can help clinicians in identifying high-risk patients and tailoring individualized interventions.

求助全文
约1分钟内获得全文 求助全文
来源期刊
American journal of translational research
American journal of translational research ONCOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
自引率
0.00%
发文量
552
期刊介绍: Information not localized
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信