Time-frequency and functional connectivity analysis in drug-naive adolescents with depression based on electroencephalography using a visual cognitive task: A comparative study.
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引用次数: 0
Abstract
Background: Previous research studies have demonstrated cognitive deficits in adolescents with depression; however, the neuroelectrophysiological mechanisms underlying these deficits remain poorly understood. Utilizing electroencephalography (EEG) data collected during cognitive tasks, this study applies time-frequency analysis and functional connectivity (FC) techniques to explore the neuroelectrophysiological alterations associated with cognitive deficits in adolescents with depression.
Methods: A total of 173 adolescents with depression and 126 healthy controls (HC) participated in the study, undergoing EEG while performing a visual oddball task. Delta, theta, and alpha power spectra, along with FC, were calculated and analyzed.
Results: Adolescents with depression exhibited significantly reduced delta, theta, and alpha power at the Fz, Cz, C5, C6, Pz, P5, and P6 electrodes compared to the HC group. Notably, theta power at the F5 electrode and alpha power at the F5 and F6 electrodes were significantly lower in the depression group than in the HC group. Additionally, cortical FC in the frontal and central regions was markedly decreased in adolescents with depression compared to HC.
Conclusions: During cognitive tasks, adolescents with depression display distinct abnormalities in both high- and low-frequency brain oscillations, as well as reduced functional connectivity in the frontal, central, and parietal regions compared to HC. These findings offer valuable neuroelectrophysiological insights into the cognitive deficits associated with adolescent depression.
期刊介绍：
The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including:
Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents.
Diagnosis: Research on the identification and classification of childhood disorders.
Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health.
Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders.
Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health.
Genetics: Genetic factors contributing to the development of childhood disorders.
JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health.
The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.
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