A domino decarboxylative alkylation/annulation for the synthesis of pyrrolo-benzimidazolones†

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-02-25 DOI:10.1039/d5ob00093a

Chada Raji Reddy , Kolli Sai Prakash , Ejjirotu Srinivasu , Muppidi Subbarao , Shiva Kumar Kota Balaji

引用次数: 0

Abstract

In this study, we report a novel, radical-promoted one-pot synthesis of pyrrolo-benzimidazolones (pyrrolo[1,2-a]benzimidazol-1-ones), involving the reaction of N-propiolyl-benzimidazole with aliphatic carboxylic acids in the presence of ammonium persulfate. A diverse range of aliphatic carboxylic acids as well as aryl N-propiolyl-benzimidazoles could participate in this oxidative domino reaction. Further transformations of the obtained pyrrolo-benzimidazolone were also demonstrated.

Abstract Image

查看原文本刊更多论文

合成吡咯-苯并咪唑酮的多米诺脱羧烷基化/环化反应。

在这项研究中，我们报道了一种新的，自由基促进的一锅合成吡咯-苯并咪唑酮（pyrrolo[1,2-a]苯并咪唑-1-ones），涉及n -丙酰苯并咪唑与脂肪族羧酸在过硫酸铵存在下的反应。多种脂肪族羧酸以及芳基n -丙酰苯并咪唑都可能参与这种氧化多米诺反应。得到的吡咯-苯并咪唑酮的进一步转化也得到了证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.