Diverse Bone Matrix and Mineral Alterations in Osteoporosis with Different Causes: A Solid-State NMR Study.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-05-12 Epub Date: 2025-03-17 DOI:10.1021/acsbiomaterials.4c01581

Jing-Yu Lin, Xu Guo, Ming-Hui Sun, Yifeng Zhang, Jun-Xia Lu

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引用次数: 0

Abstract

Osteoporosis (OP), which is a common skeletal disease with different causes, is prevalent in the aging population. Postmenopause women generally suffer from OP with bone loss due to estrogen deficiency. Diabetes is also associated with OP by complex metabolic mechanisms. Bone qualities of OP caused by aging were compared with those of the ovariectomy (OVX) model and the Type 2 diabetic model using Sprague-Dawley (SD) rats in our study. Combining with micro-computed tomography (μ-CT) and solid-state NMR (SSNMR) methods, this research studied bone changes in SD rats from tissue level to the molecular level. The studies revealed bone loss was most significant for cancellous bones but not for cortical bones in OP rats. However, at the molecular level, the content of HAP in cortical bone increased with aging, contributing to the brittleness of the bone. Triglyceride, as a senescence maker of osteocyte in cortical bone, was also identified to be closely associated with OP in aging and OVX rats but not in diabetic rats. This research suggests that changes of bone quality at the molecular level more objectively reflect the bone tissue reconstruction of OP with various causes rather than mere bone loss revealed by μ-CT analysis.

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不同原因骨质疏松症的不同骨基质和矿物质改变：一项固体核磁共振研究。

骨质疏松症（Osteoporosis， OP）是一种常见的骨骼疾病，其病因多种多样。绝经后的女性通常会因雌激素缺乏而伴有骨质流失。糖尿病也通过复杂的代谢机制与OP相关。本研究采用SD大鼠（Sprague-Dawley， SD）与卵巢切除（OVX）模型和2型糖尿病模型的骨质量进行比较。结合微计算机断层扫描（μ-CT）和固态核磁共振（SSNMR）技术，从组织水平到分子水平研究SD大鼠的骨变化。研究表明，骨量损失在OP大鼠中以松质骨最为显著，而皮质骨不明显。但在分子水平上，皮质骨中HAP的含量随着年龄的增长而增加，导致骨的脆性。甘油三酯作为皮质骨中骨细胞的促衰老因子，也被发现与衰老和OVX大鼠的OP密切相关，但与糖尿病大鼠无关。本研究提示，分子水平上骨质量的变化更客观地反映了OP各种原因的骨组织重建，而不仅仅是μ-CT分析所显示的骨质流失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture