Polymeric Nanosystems: A Breakthrough Approach to Treating Inflammation and Inflammation Related Diseases

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biopolymers Pub Date : 2025-03-19 DOI:10.1002/bip.70012

Maja D. Markovic, Vesna V. Panic, Rada V. Pjanovic

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引用次数: 0

Abstract

Inflammation processes can cause mild to severe damage in the human body and can lead to a large number of inflammation-related diseases (IRD) such as cancer, neural, vascular, and pulmonary diseases. Limitations of anti-inflammatory drugs (AID) application are reflected in high therapeutic doses, toxicity, low bioavailability and solubility, side effects, etc. Polymeric nanosystems (PS) have been recognized as a safe and effective technology that is able to overcome these limitations by AID encapsulation and is able to answer to the specific demands of the IRD treatment. PS are attracting great attention due to their versatility, biocompatibility, low toxicity, fine-tuned properties, functionality, and ability for precise delivery of anti-inflammatory drugs to the targeted sites in the human body. This article offers an overview of three classes of polymeric nanosystems: a) dendrimers, b) polymeric micelles and polymeric nanoparticles, and c) polymeric filomicelles, as well as their properties, preparation, and application in IRD treatment. In the future, the number of PS formulations in clinical practice will certainly increase.

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聚合物纳米系统：治疗炎症和炎症相关疾病的突破性方法

炎症过程可对人体造成轻微到严重的损害，并可导致大量炎症相关疾病（IRD），如癌症、神经、血管和肺部疾病。抗炎药应用的局限性体现在治疗剂量大、毒性大、生物利用度和溶解度低、副作用大等方面。聚合物纳米系统（PS）已经被认为是一种安全有效的技术，它能够克服AID封装的这些限制，并能够满足IRD治疗的特定要求。PS由于其多功能性、生物相容性、低毒性、精细的特性、功能性以及将抗炎药物精确递送到人体目标部位的能力而备受关注。本文概述了三类聚合物纳米系统：a)树状大分子，b)聚合物胶束和聚合物纳米粒子，c)聚合物丝束，以及它们的性质，制备和在IRD治疗中的应用。在未来的临床实践中，PS制剂的数量肯定会增加。

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来源期刊

Biopolymers 生物-生化与分子生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Founded in 1963, Biopolymers publishes strictly peer-reviewed papers examining naturally occurring and synthetic biological macromolecules. By including experimental and theoretical studies on the fundamental behaviour as well as applications of biopolymers, the journal serves the interdisciplinary biochemical, biophysical, biomaterials and biomedical research communities.