Lymphocyte Subpopulations in the Healthy Human Lacrimal Gland and Their Variations With Age and Sex, Systematic Review 1960–2023

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2025-03-19 DOI:10.1002/iid3.70167

Claudia M. Trujillo-Vargas, Luisa María Rendón-Macías, Ronald Yamil Paredes Guerrero, Cinta S. de Paiva, Jaiberth Antonio Cardona-Arias

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引用次数: 0

Abstract

Background

Immunosenescence has been associated with an imbalance in the lacrimal functional unit and histopathological changes in exocrine glands, especially in women.

Objective

To define the main lymphocyte subpopulations in the human lacrimal gland and their variations with age and sex, according to scientific articles published between 1960 and 2023.

Methods

A systematic review was performed on PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 guidelines were applied for the search and selection of studies.

The methodological quality was evaluated with the STROBE guidelines. A meta-analysis of three selected articles dichotomizing lymphocytic infiltrates according to age group was also performed.

Results

We selected 20 observational studies, including 774 healthy individuals (722 cadavers). The articles evaluated the lymphocyte infiltration with hematoxylin and eosin staining, immunohistochemistry and immunofluorescence. There was high variability in the criteria to define the apparently human lacrimal and to quantify the lymphocytic infiltration. There was an underrepresentation of individuals younger than 40 years (12.6%), and female sex (38.9%). Three articles reported an association of age and sex with lymphocytic infiltration in the healthy lacrimal gland, while two articles did not. Plasma cells were the most abundant lymphocyte subpopulation in the healthy lacrimal gland, including IgA-containing plasma cells. B cells were reported to be very scarce in the LG in two articles. In the meta-analysis of three selected articles, no statistical difference in lymphocytic infiltration was found between individuals younger and older than 60.

Conclusion

There is the need of further observational studies, better defining the study design, with similar representation across sex and ages to ascertain what are the changes of lymphocytic composition in the lacrimal gland related to age and sex. Further studies are also needed to assess the dynamics of lymphocytic populations in a more detailed manner using cutting-edge methodologies such as single-cell sequencing or transcriptomics.

Trial Registration

PROSPERO 2023 CRD42023435653 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023435653.

Abstract Image

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健康人类泪腺淋巴细胞亚群及其随年龄和性别的变化，系统综述1960-2023

免疫衰老与泪功能单位失衡和外分泌腺的组织病理学改变有关，尤其是在女性中。目的根据1960年至2023年间发表的科学论文，确定人类泪腺主要淋巴细胞亚群及其随年龄和性别的变化。方法对PubMed、ScienceDirect和谷歌Scholar进行系统评价。应用PRISMA 2020指南进行研究的检索和选择。采用STROBE指南评价方法学质量。对三篇根据年龄组进行淋巴细胞浸润二分法的文章也进行了荟萃分析。结果我们选择了20项观察性研究，包括774名健康个体（722具尸体）。用苏木精染色、伊红染色、免疫组织化学和免疫荧光法评价淋巴细胞浸润情况。在定义明显的人类泪腺和量化淋巴细胞浸润的标准上有很高的可变性。40岁以下的个体（12.6%）和女性（38.9%）的代表性不足。三篇文章报道了年龄和性别与健康泪腺淋巴细胞浸润的关系，而两篇文章没有报道。浆细胞是健康泪腺中最丰富的淋巴细胞亚群，包括含iga的浆细胞。有两篇文章报道了LG中B细胞非常稀少。在三篇文章的荟萃分析中，60岁以上和60岁以上的人在淋巴细胞浸润方面没有统计学差异。结论需要进一步的观察性研究，更好地定义研究设计，在性别和年龄上具有相似的代表性，以确定泪腺淋巴细胞组成的变化与年龄和性别的关系。还需要进一步的研究，以更详细的方式评估淋巴细胞群体的动态，使用尖端的方法，如单细胞测序或转录组学。试用注册：PROSPERO 2023 CRD42023435653可从https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023435653获得。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology