Investigating the dynamics of cytomegalovirus movement in viscoelastic Casson fluid: effects of electric and magnetic fields

IF 1.8 4区 生物学 Q3 BIOPHYSICS
Kyubok Ahn, Yesudhasan M. Gifteena Hingis, Murugan Muthtamilselvan, Qasem Al-Mdallal
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引用次数: 0

Abstract

Cytomegalovirus (CMV) is a significant clinical pathogen posing risks, especially for immunocompromised individuals. This study investigates the transport dynamics of CMV within viscoelastic saliva, focusing on factors influencing viral mobility. We employed mathematical models, including the Basset-Boussinesq-Oseen (BBO) equation, to analyze how viral density, particle diameter, saliva viscosity, and external electric and magnetic fields affect CMV movement in the oesophagus. Novel insights include the discovery that smaller CMV particles move significantly faster compared to larger ones, highlighting a critical aspect of viral infectivity. Additionally, we found that increased peristaltic wave amplitudes in the oesophagus greatly enhance viral velocity. More notably, our investigation reveals that the application of external magnetic fields can manipulate CMV transport by exerting forces that reduce viral mobility, thus potentially lowering infection rates through electromagnetic interactions. These findings underscore the complex interplay between fluid rheology, particle shape, and external fields in viral dynamics, suggesting novel therapeutic interventions aimed at controlling CMV spread based on saliva viscosity and electromagnetic manipulation. Our research paves the way for innovative strategies in viral infection management and therapeutic development.

研究巨细胞病毒在粘弹性卡森流体中的运动动力学:电场和磁场的影响
巨细胞病毒(CMV)是一种重要的临床病原体,尤其是对免疫功能低下的个体。本研究探讨了CMV在粘弹性唾液中的转运动力学,重点研究了影响病毒迁移的因素。我们采用数学模型,包括bassetboussinesq - oseen (BBO)方程,分析病毒密度、颗粒直径、唾液粘度和外部电场和磁场如何影响CMV在食道中的运动。新的见解包括发现较小的巨细胞病毒颗粒比较大的移动速度快得多,突出了病毒感染性的一个关键方面。此外,我们发现食管蠕动波振幅的增加大大提高了病毒的传播速度。更值得注意的是,我们的研究表明,外部磁场的应用可以通过施加降低病毒移动性的力来操纵巨细胞病毒的运输,从而可能通过电磁相互作用降低感染率。这些发现强调了病毒动力学中流体流变学、颗粒形状和外部场之间的复杂相互作用,提出了基于唾液粘度和电磁操纵的新型治疗干预措施,旨在控制巨细胞病毒的传播。我们的研究为病毒感染管理和治疗开发的创新策略铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Biological Physics
Journal of Biological Physics 生物-生物物理
CiteScore
3.00
自引率
5.60%
发文量
20
审稿时长
>12 weeks
期刊介绍: Many physicists are turning their attention to domains that were not traditionally part of physics and are applying the sophisticated tools of theoretical, computational and experimental physics to investigate biological processes, systems and materials. The Journal of Biological Physics provides a medium where this growing community of scientists can publish its results and discuss its aims and methods. It welcomes papers which use the tools of physics in an innovative way to study biological problems, as well as research aimed at providing a better understanding of the physical principles underlying biological processes.
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