Implementation of school-based vaccination in French middle schools: Efficient or not?

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-03-18 DOI:10.1016/j.vaccine.2025.127007

Aurelie Baldolli , Anna Fournier , Hélène Roger , Emmanuel Piednoir , Julie Clément , Anne Martin , Renaud Verdon , Jocelyn Michon

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Abstract

Introduction

Despite various vaccination campaigns coordinated by French authorities, vaccine coverage (VC) in France remains low, especially for human papillomavirus (HPV). The Agence Regionale de Santé established a mandate for vaccination centres in Normandy to develop a school-based vaccination program in public middle schools. The aim of this study was to analyse the efficiency of this program after four academic years (2019–2023).

Materials and methods

Authorization from the parents was required to update each of the following recommended vaccinations for their children (aged 11–13-years-old): diphtheria-tetanus-poliomyelitis-pertussis; hepatitis B virus (HBV); measles, mumps and rubella; meningococcal C; and HPV vaccines. Adolescents for whom at least one vaccine has been accepted were seen by the doctor and were vaccinated if needed. Global VC was defined as being vaccinated for all French mandatory and recommended vaccines. The objective of this study was to compare the proportions of global VC pre and post implementation of the school vaccination program during the period study.

Results

During the study period, 199 schools were visited. Among the 18,476 students, 33.6 % (n = 6217) of the students' parents accepted at least one vaccine, and 4464 students were vaccinated (81.9 %, 4464/5450). Global preintervention VC was 10.7 % (n = 585), which increased to 65.7 % (n = 3585) after the vaccine intervention (p < 0.0001). VC increased from 64.8 % in preintervention to 87.5 % in postintervention (p < 0.0001) for the meningococcal C vaccine, from 67.6 % to 85.6 % (p < 0.0001) for the HBV vaccine and from 14.6 % (n = 675/4614) to 79.9 % (n = 3685/4614) (p < 0.0001) for the HPV vaccine. In multivariate analysis, the post-COVID-19 period (2021−2022) was significantly associated with not being up to date for at least one vaccine (OR: 1.4 [1.2–1.9]).

Conclusion

Our study determined that school vaccination program effectively improved VC for all recommended vaccines and should not be restricted to certain vaccines, such as HPV.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.