A H2O2 responsive self-activatable fluorescent probe and pro-photosensitizer based on a pyridine-chalcone skeleton

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-03-13 DOI:10.1016/j.saa.2025.126050

Yawen Zhang , Chao Wang , Jing Zhang , Aiping Jia , Yuxia Liu , Siwei Bi , Guang Chen

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引用次数: 0

Abstract

Hydrogen peroxide (H₂O₂) is closely associated with various physiological and pathological processes, particularly in tumor microenvironment. It has been designed for the activation and release of fluorescent probes and tumor-related drugs. In this work, we proposed a self-activatable fluorescent probe and pro-photosensitizer (pro-PS) MN-BP based on a pyridine-chalcone photosensitizer (PS) MN and a H₂O₂ responsive boronate moiety. The endogenous H₂O₂ in tumor cells triggers partial release of PS MN from the pro-PS MN-BP. Under light irradiation, the generated PS MN can produce Reactive oxygen species (ROS) and be partially converted to H₂O₂ to proceed the self-activatable process. The generated H₂O₂ can be used as an activator to accelerate the release of PS MN, thus amplifying the effect of photodynamic therapy (PDT) by generating more ROS. In addition, the enhanced fluorescence of pro-PS MN-BP can be used for the detection of H₂O₂ and the visualization of photosensitizer, so as to realize the real-time monitoring and regulation of the PDT process.

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.