Electron dose optimisation based on tumour thickness and shape for photon multi-leaf collimated megavoltage electrons

IF 1.6 3区 工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR
D. van Eeden, F.C.P. du Plessis
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引用次数: 0

Abstract

This study developed an optimisation method that considers tumour thickness for modulated electron radiation treatment (MERT) at a treatment distance of 60 cm. It comprises forming a tumour bed matrix from which a transformed tumour bed matrix is derived. From the discrete tumour bed depth data, electron beam segments were extracted, which were further decomposed into sub-beams. The EGSnrc-based Monte Carlo codes BEAMnrc and DOSXYZnrc were used to model a linear accelerator and to score 3-D dose data for various field sizes (sub-beams) in a water phantom model.
The use of different energy and intensity-modulated electron sub-beams to irradiate a parotid lesion was investigated by applying the developed optimisation method. After each sub-beam energy was determined, a least square cost function minimisation was invoked to deliver a minimum dose to the tumour volume and produce a set of weight factors synonymous with beam intensity modulation.
This study describes a technique to derive apertures and suitable sub-beam energy to provide a method for planning a robust MERT technique that yields dose-covering results and dose spread within the tumour that aligns with literature studies.
基于肿瘤厚度和形状的光子多叶准直超高压电子电子剂量优化
本研究开发了一种优化方法,该方法考虑了60厘米治疗距离下调制电子辐射治疗(MERT)的肿瘤厚度。它包括形成肿瘤床矩阵,从中导出转化的肿瘤床矩阵。从离散的肿瘤床深度数据中提取电子束片段,并进一步分解成子束。利用基于egsnrc的蒙特卡罗代码BEAMnrc和DOSXYZnrc对直线加速器进行建模,并对水影模型中不同场大小(子光束)的三维剂量数据进行评分。应用所开发的优化方法,研究了不同能量和强度调制的电子束照射腮腺病变的效果。在确定每个子光束能量后,调用最小二乘成本函数最小化来为肿瘤体积提供最小剂量,并产生一组与光束强度调制相同的权重因子。本研究描述了一种获得孔径和合适的子束能量的技术,为规划稳健的MERT技术提供了一种方法,该技术可以产生剂量覆盖结果和剂量在肿瘤内的扩散,这与文献研究一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Applied Radiation and Isotopes
Applied Radiation and Isotopes 工程技术-核科学技术
CiteScore
3.00
自引率
12.50%
发文量
406
审稿时长
13.5 months
期刊介绍: Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.
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