Enhanced antibacterial performance of gold nanostars under NIR irradiation: A combined photothermal and photodynamic therapy approach

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-03-15 DOI:10.1016/j.matlet.2025.138402

Xinrui Yao, Yanyan Wang, Xinran Sheng, Xiaoli He, Hongwei Wang, Lin Yuan

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引用次数: 0

Abstract

The rise of antibiotic-resistant bacteria has emerged as a critical global health issue, significantly undermining the efficacy of conventional antimicrobial therapies. In response to this challenge, a novel synergistic photothermal/photodynamic therapy (PTT/PDT) nanosystem, which is designed to generate indocyanine green (ICG)-functionalized gold nanostars (Aunst) through the incorporation of ICG onto a polydopamine (PDA)-coated Aunst framework, is introduced. This composite, referred to as Aunst@PDA-ICG, demonstrates an ability to elevate the temperature from 25.0 °C to 53.2 °C and produce reactive oxygen species (ROS) at a concentration of 0.40 mM under near-infrared (NIR) irradiation at 0.75 W/cm² within a 6-minute exposure. The antibacterial activity of Aunst@PDA-ICG was assessed against Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative Pseudomonas aeruginosa (P. aeruginosa). Under NIR irradiation, the antibacterial efficacy of Aunst@PDA-ICG reached nearly 100 % at a concentration of 100 μg/mL for both bacterial strains. Furthermore, the nanocomposite exhibited excellent biocompatibility, suggesting its potential as a promising candidate for PTT/PDT-based antibacterial therapy in biomedical applications.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive