Comparative evaluation of Pluronic® micelles encapsulation efficiency for a diverse range of hydrophobic drugs: Implications for drug delivery

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2025-03-14 DOI:10.1016/j.jics.2025.101670

Sunil Desai , Deep Bhalani , Dhruv Jasoliya , Vinaydeep Punetha , Shital D. Modi , Debes Ray , Vinod K. Aswal , Sadafara A. Pillai

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Abstract

The encapsulation of hydrophobic drugs within micellar carriers is a promising approach to improve their solubility, stability, and bioavailability. In this study, we conduct a thorough comparative analysis of the encapsulation capability of Pluronic® 103 micelle, known for its unique amphiphilic nature, which serves as nano-carriers for three hydrophobic drugs, viz. meloxicam, norfloxacin, and flurbiprofen. These drugs were chosen for their varying chemical structures and physicochemical properties. The interaction of these drugs with polymeric micelles was checked using Fourier transform infrared spectroscopy (FT-IR). Further, the study investigates the influence of salt on the micellar size and drug-loading efficiency of Pluronic® micelles for different drugs using a plethora of techniques such as dynamic light scattering (DLS), small angle neutron scattering (SANS), and high-performance liquid chromatography. Our results indicate that the presence of salt promotes micellization and significant differences in encapsulation efficiency among the drugs were noted, attributed to the interplay between the drug's hydrophobicity and the micellar core's compatibility. Further, the experimental findings revealed that Norfloxacin exhibited the highest encapsulation efficiency, while meloxicam showed the minimum. The outcomes of the study provide valuable insights into the drug-specific encapsulation behavior of Pluronic® micelles, offering guidance for the design of micellar drug delivery systems tailored to specific therapeutic agents.

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Pluronic®胶束包封效率对多种疏水药物的比较评价：对药物传递的影响

将疏水药物包封在胶束载体内是提高其溶解度、稳定性和生物利用度的一种很有前途的方法。在这项研究中，我们对Pluronic®103胶束的封装能力进行了全面的比较分析，该胶束以其独特的两亲性而闻名，可作为三种疏水药物的纳米载体，即美洛昔康，诺氟沙星和氟比洛芬。选择这些药物是因为它们具有不同的化学结构和物理化学性质。利用傅里叶变换红外光谱（FT-IR）检测了这些药物与聚合物胶束的相互作用。此外，本研究还利用动态光散射（DLS）、小角中子散射（SANS）和高效液相色谱等多种技术研究了盐对Pluronic®胶束尺寸和载药效率的影响。我们的研究结果表明，盐的存在促进了胶束的形成，并且由于药物的疏水性和胶束核的相容性之间的相互作用，药物之间的包封效率存在显著差异。此外，实验结果表明，诺氟沙星的包封效率最高，美洛昔康的包封效率最低。该研究结果为Pluronic®胶束的药物特异性包封行为提供了有价值的见解，为设计针对特定治疗剂的胶束药物输送系统提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.