Advances in microbial degradation of skatole: A review

Abstract

In recent years, foul odors have led to widespread public complaints and have become a prominent issue in the field of environmental protection. Skatole, as one of the important components of foul odors, is a decomposition product of tryptophan in the intestines of animals and is mainly found in animal feces. Skatole not only has significant pulmonary toxicity to animals but also poses potential carcinogenic risks to humans. The biological method of removing skatole has the notable advantages of being cost-effective, efficient, and environmentally friendly. However, current research on the microbial degradation of skatole is still insufficient, the metabolic pathways for microbial degradation of skatole are not yet fully elucidated, and there is a lack of research on the functional genes involved in degradation. This review outlines skatole's production and distribution in solid, liquid, and gas media, identifies microorganisms capable of skatole degradation, and examines the microbial degradation mechanisms and influencing factors. Additionally, we summarize the hydroxyindole oxidative ring-opening pathway for skatole degradation in anaerobic conditions and multiple aerobic pathways, including oxidative ring-opening and ring-cleaving. Catechol 1,2-dioxygenase is proposed as a key enzyme in the downstream metabolism of microbial skatole degradation, offering guidance for future research.