Pablo E. Gaztañaga*, Eleonora Freire Espeleta and Daniel R. Vega,
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引用次数: 0
Abstract
Cocrystals of pregabalin (PGB) with different carboxylic acids were developed, and their crystal structures were determined by single crystal X-ray diffraction. All obtained cocrystal structures were isostructural and related to the free PGB crystal structure (PGB_AN). These structural similarities result in analogous thermal behavior: upon heating, cocrystals segregate, with PGB_AN as one of the final products. Notably, cocrystals formed with octanoic acid exhibited multiple single crystal to single crystal phase transitions upon heating. Initially, the 1:1 stoichiometric sample exhibited a disproportion transition at 44 °C. As a result, the single crystal is a new cocrystal of 1:2 stoichiometry. Further heating induced segregation, ultimately yielding a PGB_AN single crystal. Similar behavior was observed in cocrystals with decanoic acid, but a different structure is observed in the 1:2 stoichiometry cocrystal.
期刊介绍：
The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials.
Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.
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