Personalized cervical plug combines mechanical and biological regulation for enhanced embryo implantation and live births

IF 17.3 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Matter Pub Date : 2025-03-18 DOI:10.1016/j.matt.2025.102043

Mei Chen, Mengyuan Dai, Gonghua Hong, Fangyuan Li, Yue Wu, Yiran Pu, Jialing Liu, Yaoyao Zhang, Wei Huang, Junling Guo

{"title":"Personalized cervical plug combines mechanical and biological regulation for enhanced embryo implantation and live births","authors":"Mei Chen, Mengyuan Dai, Gonghua Hong, Fangyuan Li, Yue Wu, Yiran Pu, Jialing Liu, Yaoyao Zhang, Wei Huang, Junling Guo","doi":"10.1016/j.matt.2025.102043","DOIUrl":null,"url":null,"abstract":"Declining birth rates and widespread infertility highlight the urgency of addressing the global population crisis. Despite advancements in in vitro fertilization (IVF) embryo transfer, low implantation rates due to uterine peristalsis and insufficient embryo-endometrium interaction leads to low pregnancy rate and live births. We introduce a personalized, 3D-printed cervical plugging device (CervPlug), tailored to individual cervical dimensions. This non-invasive, patient-friendly intervention effectively improves embryo residence time in the uterus, enhancing embryo-endometrium contact and achieving efficient live births. Moreover, CervPlug also facilitates biological regulation by integrating a supramolecular phenolic nanocomplex composed of green tea polyphenol and Zn2+ ions. This enables controlled release of progesterone, reduces cervical inflammation, and lowers intra-embryonic reactive oxygen species (ROS). In vivo experiments demonstrate that CervPlug significantly increases implantation rates from 45% to 65% and live births, with no significant adverse effects on the reproductive system. This biomaterial-driven strategy offers a safer, less intrusive alternative in reproductive medicine.","PeriodicalId":388,"journal":{"name":"Matter","volume":"16 1","pages":""},"PeriodicalIF":17.3000,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Matter","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1016/j.matt.2025.102043","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Declining birth rates and widespread infertility highlight the urgency of addressing the global population crisis. Despite advancements in in vitro fertilization (IVF) embryo transfer, low implantation rates due to uterine peristalsis and insufficient embryo-endometrium interaction leads to low pregnancy rate and live births. We introduce a personalized, 3D-printed cervical plugging device (CervPlug), tailored to individual cervical dimensions. This non-invasive, patient-friendly intervention effectively improves embryo residence time in the uterus, enhancing embryo-endometrium contact and achieving efficient live births. Moreover, CervPlug also facilitates biological regulation by integrating a supramolecular phenolic nanocomplex composed of green tea polyphenol and Zn²⁺ ions. This enables controlled release of progesterone, reduces cervical inflammation, and lowers intra-embryonic reactive oxygen species (ROS). In vivo experiments demonstrate that CervPlug significantly increases implantation rates from 45% to 65% and live births, with no significant adverse effects on the reproductive system. This biomaterial-driven strategy offers a safer, less intrusive alternative in reproductive medicine.

Abstract Image

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

26.30

自引率

2.60%

发文量

367

期刊介绍： Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.