Optical Microneedle-Enhanced Transdermal Light Scattering for In Situ Photothermal Therapy Targeting Basal-Layer Psoriasis

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-03-18 DOI:10.1021/acsami.4c23014

Ze Qiang Zhao, Shi Long Zhang, Ruixing Yu, Zi Yi Wang, Xingyao Sun, Zhuo Wen Zhang, Xin Yao Geng, Ling Liang, Yong Cui, Bo Zhi Chen, Xin Dong Guo

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Abstract

Near-infrared (NIR) light-mediated photothermal and photodynamic therapies are promising for nonsurgical treatment of skin diseases. However, the skin’s inherent light absorption, especially from melanin in the epidermis, attenuates NIR energy penetration, limiting photothermal efficacy and potentially causing off-target tissue damage. In this context, we developed subcutaneous light response-enhanced microneedles (SLE MNs) that allow basal layer-localized seeding of therapeutics and leverage physical channels to efficiently transmit light transdermally, facilitating in situ scattered light activation for enhanced photothermal and photodynamic therapy outcomes. Such ultraoptical SLE MNs facilitated NIR light penetration, achieving up to 80% of initial light power at 500 μm subcutaneously, representing an approximate 160% increase compared to the control groups. Additionally, we conceptualized a two-segmented MN structure integrating light-guiding channels with photoresponsive therapeutics to enable precise in situ basal-layer treatment, effectively mitigating local hyperenergy on the skin surface and energy attenuation within tissues. This optical SLE MN patch offers a transformative platform for transdermal light therapy with significant clinical potential.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.