X-L. Zhang , F-B. Li , L. Li , Y. Liang , H-J. Zhang
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引用次数: 0
Abstract
Objectives
Hospital-acquired infections (HAIs) pose a significant risk to hospitalized patients. This study aimed to assess the relationship between the use of medication and the occurrence of HAIs.
Methods
This retrospective multi-centre case–control study included 604 HAI cases reported across three hospitals in north-west China from January 2023 to July 2024. The control group consisted of 604 patients without HAIs from the same period and same hospitals. Multi-variable log-binomial regression was performed to assess the association between use of medication and HAIs, adjusting for confounding variables. A trend Chi-squared test was used to evaluate whether the risk of HAIs increased with prolonged use of medication.
Results
Univariate analysis revealed that the use of proton pump inhibitors (PPIs), antibiotics, glucocorticoids and H2 receptor blockers increased the risk of HAIs significantly (P<0.05). Multi-variable log-binomial regression indicated that the use of PPIs, glucocorticoids and H2 receptor antagonists was associated with increased risk of HAIs, with relative risks of 1.37 [95% confidence interval (CI) 1.19–1.57], 1.33 (95% CI 1.10–1.62) and 1.84 (95% CI 1.04–3.24), respectively. The period of use of PPIs and glucocorticoids was significantly longer in the case group.
Conclusions
Use of glucocorticoids, PPIs and H2 receptor antagonists increases the risk of HAIs, with prolonged use exacerbating this risk. The use of a single antibiotic for up to 10 days is not associated with HAI acquisition.
期刊介绍:
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.