XiaoLiang Zhang, FangBin Li, Lin Li, Yan Liang, HaoJun Zhang
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引用次数: 0
Abstract
Objectives: Hospital-acquired infections (HAIs) pose a significant risk to hospitalised patients. This study aimed to assess the relationship between medication use and the occurrence of HAIs.
Methods: This retrospective multicentre case -control study included 604 HAI cases reported across three hospitals in northwest China from January 2023 to July 2024. The control group consisted of 604 patients without HAIs from the same period and same hospitals. We performed multivariable log-binomial regression to assess the association between medication use and HAIs, adjusting for confounding variables. A trend chi-squared test was also used to evaluate if the risk of HAIs increased with longer medication durations.
Results: Univariate analysis revealed that the use of proton pump inhibitors (PPIs), antibiotics, glucocorticoids, and H2 receptor blockers significantly increased the risk of HAIs (P < 0.05. Multivariable log-binomial regression indicated that PPIs, glucocorticoids, and H2 receptor antagonists were associated with an elevated risk of HAIs, with relative risks (RRs) of 1.37 (95% CI: 1.19-1.57), 1.33 (95% CI: 1.10-1.62), and 1.84 (95% CI: 1.04-3.24), respectively. The duration of prolonged use of PPIs and glucocorticoids was significantly longer in the case group.
Conclusions: Glucocorticoids, PPIs, and H2 receptor antagonists increase HAI risk, with prolonged use exacerbating this risk. The use of a single antibiotic for up to 10 days is not associated with HAI acquisition.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
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