Alpha-Oscillatory Current Application Impacts Prospective Remembering Through Strategic Monitoring.

Abstract

Prospective memory (PM) is the ability to remember to execute future intentions. PM requires engagement of attentional networks, in which oscillatory activity in the alpha frequency range has been implicated. The left dorsolateral prefrontal cortex (DLPFC) and inferior parietal cortex are assumed to be engaged during PM tasks. We hypothesized that the selective application of transcranial alternating current stimulation (tACS) at alpha frequency to these areas can modulate PM-associated event-related potentials. Participants were assigned to alpha-tACS, theta-tACS, or Sham stimulation. They performed a working memory task (OGT), with a PM component, pre-, during, and post-stimulation. EEG was recorded post-stimulation. Accuracy and reaction times (RTs) were computed. Following EEG source reconstruction of mean amplitude, source activity was contrasted between conditions in which performance was modulated by tACS using cluster-based permutation tests. RTs were slower on introducing the PM task, consistent with strategic monitoring. PM accuracy improved in the alpha-tACS group only. During PM trials, source activity in the posterior cingulate cortex (PCC) was lower following alpha-tACS than after Sham stimulation. Source activity in the DLPFC following alpha-tACS was lower during PM than in OGT trials following alpha-tACS. Performance modulation through alpha-tACS, and the lower DLPFC activity in PM than in OGT trials provide evidence of a role for alpha oscillations during strategic monitoring for a PM cue. Lower PCC activity in the alpha-tACS than Sham group is consistent with facilitation of disengagement of the default mode network, supporting re-direction of attention from the OGT to the PM task and task-switching.