Lymphoid malignancies in patients with Shwachman-Diamond syndrome.

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2025-05-22 DOI:10.1182/blood.2024026507

Helen D Reed, Hyunwoo Do, Edie Weller, Marian H Harris, Christopher R Reilly, Harrison K Tsai, Jason E Farrar, Bonnie W Lau, Lauren Pommert, Christopher Gamper, Ian Atkinson, Katherine Coyne, Margret Joos, Sara Loveless, Sarah Steltz, Leah Cheng, Maggie Malsch, Kasiani Myers, Akiko Shimamura

引用次数: 0

Abstract

Abstract: This study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population data. Increased toxicity was observed with standard therapies in patients with SDS.

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Shwachman-Diamond综合征患者的淋巴系统恶性肿瘤。

该研究确定了Shwachman-Diamond综合征的淋巴细胞恶性肿瘤风险增加，观察到的风险比基于人群数据的预期高38倍。在SDS患者中，采用标准疗法观察到毒性增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.