Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia.

IF 21 1区医学 Q1 HEMATOLOGY

Blood Pub Date : 2025-05-29 DOI:10.1182/blood.2024027034

Nora M Gibson, Eugene Khandros, Caitlin W Elgarten, Elizabeth Worster, Dimitrios S Monos, Alexis A Thompson, Janet L Kwiatkowski, Timothy S Olson

引用次数: 0

Abstract

Abstract: We report our single-center experience demonstrating that HLA class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications, and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent β thalassemia.

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HLA异体免疫对基因修饰的自体干细胞移植治疗输血依赖性地中海贫血的影响。

我们报告了我们的单中心经验，证明HLA I类异体免疫预测在接受基因修饰的造血干细胞移植治疗输血依赖性地中海贫血的患者中血小板植入时间更长，出血并发症增加，输血需求更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood 医学-血液学

CiteScore

23.60

自引率

3.90%

发文量

955

审稿时长

1 months

期刊介绍： Blood, the official journal of the American Society of Hematology, published online and in print, provides an international forum for the publication of original articles describing basic laboratory, translational, and clinical investigations in hematology. Primary research articles will be published under the following scientific categories: Clinical Trials and Observations; Gene Therapy; Hematopoiesis and Stem Cells; Immunobiology and Immunotherapy scope; Myeloid Neoplasia; Lymphoid Neoplasia; Phagocytes, Granulocytes and Myelopoiesis; Platelets and Thrombopoiesis; Red Cells, Iron and Erythropoiesis; Thrombosis and Hemostasis; Transfusion Medicine; Transplantation; and Vascular Biology. Papers can be listed under more than one category as appropriate.