Influence of Left Ventricular Mass Index on Clinical Outcomes in Patients with Acute Myocardial Infarction.

Abstract

The aim of this study was to analyze the correlation between left ventricular mass index (LVMI) and the prognosis of patients with acute myocardial infarction (AMI).The study retrospectively analyzed the Registry of New-onset Atrial Fibrillation Complicating Acute Myocardial Infarction-Shanghai database and included 1957 patients with AMI who were hospitalized from February 2014 to March 2018, with a median follow-up of 2.7 ± 1.3 years; it calculated the number of all-cause mortalities after AMI. Through receiver operating characteristic curve analysis of LVMI, the optimal LVMI cutoff value was obtained, and the enrolled patients were grouped accordingly. The effects of different LVMI levels on the occurrence of cardiovascular and cerebrovascular adverse events were evaluated in patients with AMI. In addition, the risk assessment and prognostic value of the combined application of LVMI and the GRACE score was explored in patients with AMI.The incidences of all-cause mortality, cardiovascular death, heart failure readmission rate, and reinfarction in patients with AMI in LVMI ≥ 98.90 group were significantly higher than those in LVMI < 98.90 group (P< 0.05). The value of LVMI combined with the GRACE score in predicting the risk of post-AMI all-cause mortality as well as cardiovascular death seemed to be better than that of using the GRACE score alone. LVMI, old age, male sex, renal insufficiency, previous heart failure, stroke history, and decreased left ventricular ejection fraction were independent risk factors for all-cause mortality after AMI.High LVMI may be closely associated with all-cause mortality and adverse cardiovascular events after AMI, especially in patients with AMI with LVMI > 98.9. The risk of all-cause mortality after AMI can also be assessed in combination with LVMI and GRACE scores.