Frontispiz: Ultrasensitive Characterization of Native Bacterial Biofilms via Dynamic Nuclear Polarization-Enhanced Solid-State NMR

Chang-Hyeock Byeon, Ted Kinney, Dr. Hakan Saricayir, Kasper Holst Hansen, Dr. Faith J. Scott, Sadhana Srinivasa, Meghan K. Wells, Dr. Frederic Mentink-Vigier, Prof. Wook Kim, Prof. Ümit Akbey
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Abstract

Ultrasensitive characterization of native bacterial biofilm: A high-sensitivity dynamic nuclear polarization (DNP) enhanced solid-state NMR method illuminates the composition of intact native bacterial biofilm. The DNP sensitivity boost (~75-fold) allows observing NMR signals of biofilms composed of bacteria and extracellular matrix at natural abundance, shown here for Pseudomonas. Chemical identification quantifies the biofilm components, as reported by Ümit Akbey et^^al. in their Research Article (e202418146).

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来源期刊
Angewandte Chemie
Angewandte Chemie 化学科学, 有机化学, 有机合成
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