4D Bioprinted Self-Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea (Adv. Mater. Technol. 6/2025)

Abstract

4D Bioprinted Self-Folding Scaffolds

In article number 2401210, Riccardo Gottardi, Carmelo DeMaria, and co-workers present the fabrication via extrusion bioprinting of a bilayer scaffold programmed to self-fold after the printing to mimic the human tracheal anatomy. The scaffold is populated by human cells and supports the maturation of healthy cartilage in its outer part. The design of the scaffold was guided by mathematical modeling.