Piezoelectric Biomaterials for Use in Bone Tissue Engineering—A Narrative Review

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-03-17 DOI:10.1002/jbm.b.35564

Sandeep Choudhury, Debolina Das, Sandipan Roy, Amit Roy Chowdhury

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引用次数: 0

Abstract

To examine natural bone's bioelectrical traits, notably its piezoelectricity, and to look into how these characteristics influence bone growth and repair. In the context of exploring the potential of piezoelectric biomaterials, such as biopolymers and bio-ceramics, towards orthopedic and bone regeneration applications, the research seeks to evaluate the significance of piezoelectricity-driven osteogenesis. The paper reviews recent research on bone's electrical and dielectric properties, surface polarization/electrical stimulation effects interacting with cell activity and the effectiveness of piezoelectric biomaterials to support tissues' regenerative process. The study includes a number of materials, such as collagen, polyvinylidene fluoride (PVDF) and barium titanate. The applications of piezoelectric bio-ceramics, piezoelectric organic polymers, and piezoelectric natural polymers are particularly highlighted. Piezoelectric biomaterials are being shown in recent studies to enhance cellular metabolism in vitro as well as promote the regeneration of tissues in vivo, especially when paired with electric field stimulation or interface polarization. Piezoelectric bio-ceramics like magnesium silicate and barium titanate, as well as biopolymers like collagen and PVDF, have shown possibilities for orthopedic applications. However, there are several challenges regarding the manufacturing of bio-ceramics of specific compositions having the desired properties. This review highlighted the potential of piezoelectric biomaterials in orthopedic applications with special emphasis on biopolymers and bioceramics. Therefore, these types of materials have huge potential for bone regeneration because they can mimic the piezoelectric properties of bone and allow better advances in tissue engineering or regenerative medicine. To date, little is known about their mechanism of action, and modifications are needed to improve efficacy for clinical uptake.

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压电生物材料在骨组织工程中的应用综述

研究天然骨的生物电特性，特别是其压电性，并研究这些特性如何影响骨的生长和修复。在探索压电生物材料（如生物聚合物和生物陶瓷）在骨科和骨再生应用方面的潜力的背景下，该研究旨在评估压电驱动成骨的意义。本文综述了近年来在骨的电学和介电特性、表面极化/电刺激效应与细胞活性的相互作用以及压电生物材料支持组织再生过程的有效性等方面的研究进展。该研究包括许多材料，如胶原蛋白、聚偏氟乙烯（PVDF）和钛酸钡。压电生物陶瓷、压电有机聚合物和压电天然聚合物的应用尤为突出。最近的研究表明，压电生物材料在体外增强细胞代谢和促进体内组织再生，特别是在电场刺激或界面极化的情况下。压电生物陶瓷，如硅酸镁和钛酸钡，以及生物聚合物，如胶原蛋白和PVDF，已经显示出矫形应用的可能性。然而，关于制造具有所需性能的特定组合物的生物陶瓷存在一些挑战。本文综述了压电生物材料在骨科领域的应用潜力，特别强调了生物聚合物和生物陶瓷。因此，这些类型的材料具有巨大的骨再生潜力，因为它们可以模拟骨的压电特性，并使组织工程或再生医学取得更好的进展。迄今为止，对其作用机制知之甚少，需要修改以提高临床吸收的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.