Early Development and Co-Evolution of Microstructural and Functional Brain Connectomes: A Multi-Modal MRI Study in Preterm and Full-Term Infants

IF 3.5 2区 医学 Q1 NEUROIMAGING
Andrea Gondová, Sara Neumane, Tomoki Arichi, Jessica Dubois
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Abstract

Functional networks characterized by coherent neural activity across distributed brain regions have been observed to emerge early in neurodevelopment. Synchronized maturation across regions that relate to functional connectivity (FC) could be partially reflected in the developmental changes in underlying microstructure. Nevertheless, covariation of regional microstructural properties, termed “microstructural connectivity” (MC), and its relationship to the emergence of functional specialization during the early neurodevelopmental period remain poorly understood. We investigated the evolution of MC and FC postnatally across a set of cortical and subcortical regions, focusing on 45 preterm infants scanned longitudinally, and compared to 45 matched full-term neonates as part of the developing Human Connectome Project (dHCP) using direct comparisons of grey-matter connectivity strengths as well as network-based analyses. Our findings revealed a global strengthening of both MC and FC with age, with connection-specific variability influenced by the connection maturational stage. Prematurity at term-equivalent age was associated with significant connectivity disruptions, particularly in FC. During the preterm period, direct comparisons of MC and FC strength showed a positive linear relationship, which seemed to weaken with development. On the other hand, overlaps between MC- and FC-derived networks (estimated with Mutual Information) increased with age, suggesting a potential convergence towards a shared underlying network structure that may support the co-evolution of microstructural and functional systems. Our study offers novel insights into the dynamic interplay between microstructural and functional brain development and highlights the potential of MC as a complementary descriptor for characterizing brain network development and alterations due to perinatal insults such as premature birth.

Abstract Image

微结构和功能性脑连接体的早期发育和共同进化:早产儿和足月婴儿的多模态MRI研究
功能网络的特点是连贯的神经活动跨越分布的大脑区域已被观察到出现在早期的神经发育。与功能连接(FC)相关的区域的同步成熟可以部分反映在底层微观结构的发育变化中。然而,被称为“微结构连通性”(MC)的区域微结构特性的共变及其与早期神经发育时期功能特化的关系仍然知之甚少。作为发展中的人类连接组项目(dHCP)的一部分,我们通过灰质连接强度的直接比较以及基于网络的分析,对45名早产儿进行纵向扫描,并与45名匹配的足月新生儿进行比较,研究了出生后皮层和皮层下区域的MC和FC的进化。我们的研究结果显示,随着年龄的增长,MC和FC在全球范围内都有增强,连接的特异性变异受连接成熟阶段的影响。足月年龄早产与显著的连接中断有关,尤其是FC。在早产期间,MC和FC强度的直接比较呈正线性关系,随着发育而减弱。另一方面,MC-和fc -衍生网络之间的重叠(根据互信息估计)随着年龄的增长而增加,这表明可能会趋同于共享的底层网络结构,这可能支持微观结构和功能系统的共同进化。我们的研究为微观结构和大脑功能发育之间的动态相互作用提供了新的见解,并强调了MC作为描述围产期损伤(如早产)导致的大脑网络发育和改变的补充描述的潜力。
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来源期刊
Human Brain Mapping
Human Brain Mapping 医学-核医学
CiteScore
8.30
自引率
6.20%
发文量
401
审稿时长
3-6 weeks
期刊介绍: Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.
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