L. A. Ostrovskaya, D. B. Korman, E. I. Nekrasova, N. V. Bluhterova, U. A. Hochenkova, K. A. Abzaeva
{"title":"The Cytotoxicity of Gold and Silver Polyacrylates for Tumor Cells","authors":"L. A. Ostrovskaya, D. B. Korman, E. I. Nekrasova, N. V. Bluhterova, U. A. Hochenkova, K. A. Abzaeva","doi":"10.1134/S0006350924701148","DOIUrl":null,"url":null,"abstract":"<div><p>A study of the cytotoxic activities of two polyacrylic acid-based compounds containing gold (aurumacryl) and silver (argacryl) against a panel of human tumor cell cultures (769-P, Caki-2, SK-RC-1 renal carcinoma lines, BT-474 breast carcinoma, and NCI-H211 small cell lung carcinoma) was carried out <i>in vitro</i>. The results we obtained were analyzed in comparison with the data established earlier for other cell cultures (MCF-7 breast carcinoma, A-549 lung carcinoma, HCT116 colon carcinoma, and Mel Me melanoma). The <i>IC</i><sub>50</sub> cytotoxic index of drugs for the nine tested tumor cell lines ranged from 0.8 to 5.2 μg/mL for aurumacryl and from 0.2 to 14.4 μg/mL for argacryl (in terms of gold and silver content, respectively), depending on the type of tumor. Significant differences were found in the spectra of the lethal effects of aurumacryl and argacryl against tumor cells of various types.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 6","pages":"1054 - 1059"},"PeriodicalIF":4.0330,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350924701148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
A study of the cytotoxic activities of two polyacrylic acid-based compounds containing gold (aurumacryl) and silver (argacryl) against a panel of human tumor cell cultures (769-P, Caki-2, SK-RC-1 renal carcinoma lines, BT-474 breast carcinoma, and NCI-H211 small cell lung carcinoma) was carried out in vitro. The results we obtained were analyzed in comparison with the data established earlier for other cell cultures (MCF-7 breast carcinoma, A-549 lung carcinoma, HCT116 colon carcinoma, and Mel Me melanoma). The IC50 cytotoxic index of drugs for the nine tested tumor cell lines ranged from 0.8 to 5.2 μg/mL for aurumacryl and from 0.2 to 14.4 μg/mL for argacryl (in terms of gold and silver content, respectively), depending on the type of tumor. Significant differences were found in the spectra of the lethal effects of aurumacryl and argacryl against tumor cells of various types.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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