Peptide TRPV1 Channel Blocker, HCRG21, Effectively Suppresses Inflammation in a Calcipotriol-Induced Allergic Dermatitis Model

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
A. A. Klimovich, A. N. Kvetkina, Yu. V. Deryavko, N. A. Priymenko, E. V. Leychenko
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引用次数: 0

Abstract

As a result of application of hydrogels with 0.05 and 0.005% HCRG21 calcipotriol-induced inflammatory swelling and flaking of the auricle were significantly reduced. As a result of application of hydrogels with 0.05 and 0.005% HCRG21 calcipotriol-induced inflammatory swelling and flaking of the auricle were significantly reduced. Treatment with HCRG21 normalized peripheral blood parameters in mice, including total white blood cell count and basophil percentage. In addition, treatment with gels containing HCRG21 resulted in a decrease in the level of proinflammatory cytokines: interleukin-23 (IL-23) and macrophage-derived chemokine (MDC) by 1.5 and 2 times, respectively, compared to the control group of animals. According to the results of histological analysis of the auricle of mice, treatment with peptide-containing gels enhanced the regeneration of the affected skin area, reducing hyperkeratosis, hyperplasia of the epidermis and dermis, and tissue hypervascularization. Thus, the discovered anti-inflammatory and regenerative effect of HCRG21 in the calcipotriol-induced allergic dermatitis model determines the potential of the peptide as a dermatotropic drug.

Abstract Image

肽TRPV1通道阻滞剂HCRG21在钙三醇诱导的过敏性皮炎模型中有效抑制炎症
应用含有0.05和0.005% HCRG21钙三醇的水凝胶后,耳廓炎症性肿胀和剥落明显减轻。应用含有0.05和0.005% HCRG21钙三醇的水凝胶后,耳廓炎症性肿胀和剥落明显减轻。HCRG21使小鼠外周血参数正常化,包括白细胞总数和嗜碱性粒细胞百分比。此外,用含有HCRG21的凝胶处理导致促炎细胞因子:白细胞介素-23 (IL-23)和巨噬细胞来源的趋化因子(MDC)的水平分别比对照组降低1.5倍和2倍。根据小鼠耳廓的组织学分析结果,含肽凝胶处理可促进患处皮肤区域的再生,减少角化过度、表皮和真皮增生以及组织血管增生。因此,在钙三醇诱导的过敏性皮炎模型中发现的HCRG21的抗炎和再生作用决定了该肽作为一种促皮药的潜力。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
31
期刊介绍: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry   covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.
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