Development and characterization of a gallic acid-infused topical emulgel for enhanced wound management: formulation and in vitro optimization

Abstract

This study aimed to develop and characterize a topical emulgel for wound management, combining gallic acid with skin-permeable excipients and optimized the gelation process for consistency and stability, ensuring ease of application and prolonged drug release. The emulgel was analyzed for physicochemical properties, including rheological and texture analysis, which assessed gel strength, viscosity, spreadability, and adherence. Drug release was evaluated using in vitro models under varying conditions to determine the optimal formulation for sustained delivery. Anti-inflammatory efficacy was also tested, revealing the gel's potential to reduce inflammation and wound symptoms. Key metrics showed spreadability ranged from 7.6 to 9.4 cm, viscosity from 3100 to 5230 cps, drug content from 81% to 94%, and cumulative drug release from 55% to 85%. These findings support the potential of topical emulgels for enhanced wound care through localized drug delivery, better patient compliance, and minimized systemic effects.