The rise of mRNA therapeutic vaccines†

Jinlu Du, Ziling Fan, Jiangming Huang, Zhengyuan Li, Hongguo Hu and Yanxia Li
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Abstract

During the COVID-19 pandemic, messenger ribonucleic acid (mRNA) vaccines were developed and approved to curb the spread of coronavirus. After over 16 billion doses of the Pfizer-BioNTech-Fosun and Moderna mRNA vaccines were administered, the immune protection and clinical value of the lipid nanoparticle (LNP) platform were fully demonstrated. Herein, we provide a detailed overview of the mRNA–LNP structure and immunogenicity function and provide mechanistic insights into the ability of the LNP to elicit an immune response to combat diseases. The challenges and solutions to address these are discussed. Finally, by learning from the fast-growing and most recent advances in mRNA therapeutic vaccines, from both pre-clinical and clinical aspects, we can further expand the mRNA platform to develop a new generation of mRNA therapeutic vaccines, satisfying unmet medical needs beyond COVID-19.

Abstract Image

mRNA治疗性疫苗的兴起
在2019冠状病毒病大流行期间,研发并批准了信使核糖核酸(mRNA)疫苗,以遏制冠状病毒的传播。经过160多亿剂辉瑞-复星和Moderna mRNA疫苗的接种,脂质纳米颗粒(LNP)平台的免疫保护作用和临床价值得到了充分证明。在此,我们提供了mRNA-LNP结构和免疫原性功能的详细概述,并提供了LNP引发免疫反应以对抗疾病的能力的机制见解。讨论了解决这些问题的挑战和解决方案。最后,通过从临床前和临床两方面学习快速发展和最新进展的mRNA治疗性疫苗,我们可以进一步扩展mRNA平台,开发新一代mRNA治疗性疫苗,满足COVID-19以外未被满足的医疗需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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