Layla Cupertino, Felipe Marrese Bersotti, Thayna Magalhães Novaes, Luis Mochizuki, Solaiman Shokur, Mohamed Bouri, Fabio Augusto Barbieri, Daniel Boari Coelho
{"title":"Effect of Medication and Freezing of Gait on Rambling and Trembling in Quiet Standing in Individuals With Parkinson's Disease.","authors":"Layla Cupertino, Felipe Marrese Bersotti, Thayna Magalhães Novaes, Luis Mochizuki, Solaiman Shokur, Mohamed Bouri, Fabio Augusto Barbieri, Daniel Boari Coelho","doi":"10.1123/mc.2024-0063","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Individuals with Parkinson's disease (PD) with freezing of gait (FoG) exhibit difficulty with changes in sensory input, indicating a potential sensorimotor integration deficit. Understanding how levodopa impacts balance particularly in FoG, is critical. As traditional postural sway measures may not fully capture the complexity of balance control, rambling and trembling decomposition of the center of pressure allows a more detailed assessment of postural control by distinguishing between supraspinal and spinal contributions, offering insights into sensorimotor integration deficits. This study aims to analyze the effects of medication and FoG on rambling and trembling in quiet standing in individuals with PD.</p><p><strong>Methods: </strong>We analyzed 13 individuals with PD with FoG (PD freezers) and 19 individuals with PD without FoG (PD nonfreezers) while quiet standing on a rigid and malleable surface under (ON) and without (OFF) dopaminergic medication. Area, root mean square, and mean velocity were calculated for rambling and trembling trajectory.</p><p><strong>Results: </strong>For the rambling, all variables were significantly higher on the malleable compared with the rigid surface. For trembling, (a) all variables were higher on the malleable compared with the rigid surface (p < .001), and (b) area and medial-lateral root mean square were significantly higher ON compared with OFF medication for both groups of participants similarly.</p><p><strong>Conclusion: </strong>Our results strengthen the evidence that PD freezers have the same postural sway in quiet posture as PD nonfreezers, using similar mechanisms to control the posture. In addition, levodopa influences spinal mechanisms more than supraspinal ones in individuals with PD in quiet standing.</p>","PeriodicalId":49795,"journal":{"name":"Motor Control","volume":" ","pages":"1-13"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Motor Control","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1123/mc.2024-0063","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Individuals with Parkinson's disease (PD) with freezing of gait (FoG) exhibit difficulty with changes in sensory input, indicating a potential sensorimotor integration deficit. Understanding how levodopa impacts balance particularly in FoG, is critical. As traditional postural sway measures may not fully capture the complexity of balance control, rambling and trembling decomposition of the center of pressure allows a more detailed assessment of postural control by distinguishing between supraspinal and spinal contributions, offering insights into sensorimotor integration deficits. This study aims to analyze the effects of medication and FoG on rambling and trembling in quiet standing in individuals with PD.
Methods: We analyzed 13 individuals with PD with FoG (PD freezers) and 19 individuals with PD without FoG (PD nonfreezers) while quiet standing on a rigid and malleable surface under (ON) and without (OFF) dopaminergic medication. Area, root mean square, and mean velocity were calculated for rambling and trembling trajectory.
Results: For the rambling, all variables were significantly higher on the malleable compared with the rigid surface. For trembling, (a) all variables were higher on the malleable compared with the rigid surface (p < .001), and (b) area and medial-lateral root mean square were significantly higher ON compared with OFF medication for both groups of participants similarly.
Conclusion: Our results strengthen the evidence that PD freezers have the same postural sway in quiet posture as PD nonfreezers, using similar mechanisms to control the posture. In addition, levodopa influences spinal mechanisms more than supraspinal ones in individuals with PD in quiet standing.
期刊介绍：
Motor Control (MC), a peer-reviewed journal, provides a multidisciplinary examination of human movement across the lifespan. To keep you abreast of current developments in the field of motor control, it offers timely coverage of important topics, including issues related to motor disorders. This international journal publishes many types of research papers, from clinical experimental to modeling and theoretical studies. These papers come from such varied disciplines as biomechanics, kinesiology, neurophysiology, neuroscience, psychology, physical medicine, and rehabilitation.
Motor Control, the official journal of the International Society of Motor Control, is designed to provide a multidisciplinary forum for the exchange of scientific information on the control of human movement across the lifespan, including issues related to motor disorders.
Motor Control encourages submission of papers from a variety of disciplines including, but not limited to, biomechanics, kinesiology, neurophysiology, neuroscience, psychology, physical medicine, and rehabilitation. This peer-reviewed journal publishes a wide variety of types of research papers including clinical experimental, modeling, and theoretical studies. To be considered for publication, papers should clearly demonstrate a contribution to the understanding of control of movement.
In addition to publishing research papers, Motor Control publishes review articles, quick communications, commentaries, target articles, and book reviews. When warranted, an entire issue may be devoted to a specific topic within the area of motor control.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
