Health-related quality of life significantly improved in obese patients with psoriatic arthritis one year after a structured weight loss intervention.

IF 2 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2025-03-14 DOI:10.1186/s42358-025-00444-9

Anton J Landgren, Annelie Bilberg, Björn Eliasson, Linda Torres, Mats Dehlin, Lennart T H Jacobsson, Ingrid Larsson, Eva Klingberg

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引用次数: 0

Abstract

Objective: In this interventional weight loss study, health-related quality of life (HRQoL), anxiety, depression and fatigue were compared at baseline (BL) and at 12 months (M12) in patients with psoriatic arthritis (PsA) and controls.

Methods: PsA patients (n = 39) between 25 and 75 years of age, with body mass index (BMI) ≥ 33 kg/m² were included in a weight loss intervention with very low energy diet (VLED) for 12 or 16 weeks depending on BL BMI < 40 or ≥ 40 kg/m². The 36-item short-form health survey (SF-36) was used to assess HRQoL. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale. Assessments were done at BL, M3, M6 and M12. As controls (n = 39), obese individuals, already planned for VLED treatment were recruited and matched for sex, age and weight to the PsA patients.

Results: In PsA patients, physical HRQoL, as demonstrated by the physical component summary (PCS) of SF-36, improved from median (IQR) 34 (25-45) at BL to 43 (34-50) at M12, p = 0.009. No significant effect on mental HRQoL, demonstrated by the mental component summary (MCS) score, was seen. Similarly in controls, PCS significantly improved (median IQR, 44 (36-50) at BL to 52 (44-55) at M12, p < 0.001), whereas no significant improvement was seen in MCS. Anxiety and depression decreased significantly in both PsA patients and controls.

Conclusions: The weight loss intervention was associated with significant improvements in physical HRQoL, as well as anxiety and depression, in PsA patients and controls.

Trial registration: ClinicalTrials.gov identifier: NCT02917434, registered on September 21, 2016, retrospectively registered.

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有组织的减肥干预一年后，伴有银屑病关节炎的肥胖患者的健康相关生活质量显著改善。

目的：在这项介入性减肥研究中，比较银屑病关节炎（PsA）患者和对照组在基线（BL）和12个月（M12）时的健康相关生活质量（HRQoL）、焦虑、抑郁和疲劳。方法：年龄在25 ~ 75岁之间，体重指数(BMI)≥33 kg/m2的PsA患者（n = 39）根据BL BMI 2进行极低能量饮食（VLED）减肥干预12或16周。采用36项健康问卷（SF-36）评估HRQoL。焦虑和抑郁采用医院焦虑抑郁量表进行评估。在BL、M3、M6和M12处进行评估。作为对照（n = 39），已计划进行VLED治疗的肥胖个体被招募，并在性别、年龄和体重方面与PsA患者相匹配。结果：PsA患者的生理HRQoL，如SF-36的物理成分汇总（PCS）所示，从BL时的中位数（IQR） 34（25-45）改善到M12时的43 (34-50),p = 0.009。心理成分总结（MCS）评分对心理HRQoL无显著影响。同样，在对照组中，PCS显著改善(中位IQR，在BL时为44(36-50)，在M12时为52 (44-55)，p结论：减肥干预与PsA患者和对照组的身体HRQoL以及焦虑和抑郁的显著改善相关。试验注册：ClinicalTrials.gov识别码：NCT02917434，于2016年9月21日注册，回顾性注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.