Global prevalence and risk factors of suicidality among head and neck cancer patients-systematic review and meta-analysis.

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-03-15 DOI:10.1007/s00520-025-09244-9

Shivani Sharma, Srivatsa Surya Vasudevan, Nakoma Walker, Gaelen Shimkus, Shriya Goyal, John Pang, Kavitha Beedupalli, Cherie-Ann O Nathan

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引用次数: 0

Abstract

Purpose: Suicidality is a pertinent issue among head and neck cancer patients. Our primary aim is to investigate the current suicidality rate among head and neck cancer (HNC) patients and evaluate risk factors associated with suicidality.

Methods: We thoroughly searched primary original research from January 2024 onwards across several databases, including PubMed, Embase, ScienceDirect, Web of Science, Scopus, and PsycINFO. Using a random-effects model, we calculated the odds ratio (OR) for risk factors and conducted a proportional meta-analysis to estimate prevalence and 95% confidence intervals (CI).

Results: Out of 15 included studies, 305,146 head and neck cancer patients were included. The global prevalence of suicidality among head and neck cancer patients was estimated at 6.8% (95% CI 2.0-20.6%). Major depressive disorder (RR = 5.13, 95% CI 3.60-7.30), psychiatric disorders (RR = 3.73, 95% CI 2.65-5.25), alcohol abuse (RR = 2.67, 95% CI 1.71-4.16), substance abuse (RR = 2.47, 95% CI 1.58-3.85), smoking/nicotine dependence (RR = 2.03, 95% CI 1.60-2.58), and functional compromise (RR = 1.74, 95% CI 1.29-2.36) were identified as significant risk factors. Subgroup analysis by geographical location revealed variations in prevalence, with Asia reporting lower rates than Europe and North America.

Conclusion: This systematic review reports the current suicidality rate associated with head and neck cancer patients. Major depressive disorder and other psychiatric comorbidities pose substantial risks requiring early intervention in mitigating the burden of suicidality.

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头颈癌患者自杀的全球患病率和危险因素——系统回顾和荟萃分析

目的：自杀是头颈癌患者的一个相关问题。我们的主要目的是调查当前头颈癌（HNC）患者的自杀率，并评估与自杀相关的危险因素。方法：我们在PubMed、Embase、ScienceDirect、Web of Science、Scopus和PsycINFO等多个数据库中全面检索了2024年1月以来的主要原始研究。使用随机效应模型，我们计算了危险因素的优势比（OR），并进行了比例荟萃分析来估计患病率和95%置信区间（CI）。结果：在纳入的15项研究中，纳入了305,146例头颈癌患者。头颈癌患者的全球自杀率估计为6.8% （95% CI 2.0-20.6%）。重度抑郁症（RR = 5.13, 95% CI 3.60-7.30）、精神障碍（RR = 3.73, 95% CI 2.65-5.25）、酒精滥用（RR = 2.67, 95% CI 1.71-4.16）、药物滥用（RR = 2.47, 95% CI 1.58-3.85）、吸烟/尼古丁依赖（RR = 2.03, 95% CI 1.60-2.58）和功能损害（RR = 1.74, 95% CI 1.29-2.36）被认为是显著的危险因素。按地理位置进行的亚组分析揭示了患病率的差异，亚洲报告的患病率低于欧洲和北美。结论：本系统综述报告了当前与头颈癌患者相关的自杀率。重度抑郁症和其他精神合并症构成重大风险，需要早期干预以减轻自杀负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.