The differences in intestinal flora and metabolites between H-type hypertension and non-H-type hypertension.

Abstract

Objective: In order to explore the differences in gut microbiota and their metabolites between patients with H-type hypertension and non-H-type hypertension.

Method: Our study included 100 hypertensive patients from the Department of Cardiology at Shaoxing Second Hospital, with 51 patients having H-type hypertension (H group) and 49 having non-H-type hypertension (non-H group). Blood samples were collected for clinical and metabolite testing, and fecal samples were collected for 16 S rRNA sequencing and metabolite testing.

Results: No significant difference in the α and β diversity of the gut microbiota between the two groups of patients were observed. However, at the phylum level, patients in the non-H group have a higher abundance of Firmicutes and a lower abundance of Actinobacteriota. At the genus level, compared to the non-H group, the H-type group has a higher abundance of Bifidobacterium; at the species level, the Non-H group has a higher abundance of Bacteroides vulgatus and lower abundances of Bacteroides stercoris and Bacteroides plebeius. In the serum of both groups, the concentrations of Acetate and Isobutyrate were significantly higher in the H group (P < 0.05), while in the feces of both groups of patients, the concentration of Malonate was significantly higher in the Non-H group.

Conclusion: The microbial sequencing shows distinct differences between the H and non-H groups, with the latter having higher Firmicutes and Bacteroides vulgatus, while the H group has more Bifidobacterium and higher serum acetate levels. These variations suggest unique gut microbiota compositions and metabolite profiles for each group.