The rising trend of MDPHP consumption: an Italian snapshot.

IF 2.3 3区医学 Q3 CHEMISTRY, ANALYTICAL

Journal of analytical toxicology Pub Date : 2025-03-15 DOI:10.1093/jat/bkaf024

Nunzia La Maida, Valeria Aquilina, Fabio Vaiano, Marco Cavallo, Carlo Alessandro Locatelli, Guido Mannaioni, Davide Arillotta, Simona Pichini, Annagiulia Di Trana, Silvia Graziano

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引用次数: 0

Abstract

Synthetic cathinones (SCs) were confirmed as the second most prevalent class of NPS in 2024, underscoring their widespread availability and use. Notably, the SCs seizure and related intoxication cases increased within the European Union, involving mostly 3-chloromethcathinone, 3-methylmethcathinone, 2-methylmethcathinone, and N-ethylnorpentedrone. Italy has observed a distinct trend, with methylendioxy pyrrolidinohexanophenone (MDPHP) emerging as a significant concern. This technical note aims to provide a comparative analysis of the most recent data concerning the emergence and the spread of MDPHP in Italy. Data from the National Early Warning System on Drugs indicate that the total amount of seized MDPHP increased from 2021 to 2024. In 2023, MDPHP-related intoxication cases peaked at 47, considering either alone or in combination with other drugs, followed by a slight decrease in 2024. In Italy, MDPHP seems to dominate the Italian black market of SCs and with two fatalities reported. This increased demand for MDPHP raises health concerns, indicating the necessity to enhance drug-related harm reduction services and improve a multidisciplinary network that provides data for understanding the complex phenomenon of NPS.

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MDPHP消费的上升趋势：意大利快照。

合成卡西酮（SCs）在2024年被确认为第二大流行的NPS类别，强调了其广泛的可获得性和使用。值得注意的是，SCs缉获和相关中毒病例在欧盟增加，主要涉及3-氯甲基卡西酮、3-甲基卡西酮、2-甲基卡西酮和n -乙基去戊二酮。意大利观察到一种明显的趋势，甲基二氧基吡咯烷二己烯酮（MDPHP）正在成为一个重大问题。本技术说明旨在对意大利MDPHP的出现和传播的最新数据进行比较分析。国家毒品预警系统的数据显示，从2021年到2024年，缉获的MDPHP总量有所增加。2023年，mdphp相关中毒病例达到47例的峰值，考虑到单独或与其他药物联合使用，随后在2024年略有下降。在意大利，MDPHP似乎主导着意大利sc黑市，并有两人死亡报告。对MDPHP需求的增加引起了健康方面的关注，表明有必要加强与毒品有关的减少危害服务，并改进一个多学科网络，为了解NPS的复杂现象提供数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of analytical toxicology 医学-毒理学

CiteScore

5.10

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Analytical Toxicology (JAT) is an international toxicology journal devoted to the timely dissemination of scientific communications concerning potentially toxic substances and drug identification, isolation, and quantitation. Since its inception in 1977, the Journal of Analytical Toxicology has striven to present state-of-the-art techniques used in toxicology labs. The peer-review process provided by the distinguished members of the Editorial Advisory Board ensures the high-quality and integrity of articles published in the Journal of Analytical Toxicology. Timely presentation of the latest toxicology developments is ensured through Technical Notes, Case Reports, and Letters to the Editor.