Long-term weight change and transition of metabolic health status in middle life and the risk of atrial fibrillation.

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart rhythm Pub Date : 2025-03-13 DOI:10.1016/j.hrthm.2025.03.1942

Jiang Li, Xiaoqing Xu, Yuefeng Yu, Ying Sun, Lingli Cai, Wenqi Shen, Bin Wang, Xiao Tan, Yingli Lu, Ningjian Wang

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引用次数: 0

Abstract

Background: The association of long-term weight change with atrial fibrillation (AF) risk remains controversial and evidence for the effect of metabolic health transition on AF is limited.

Objective: To evaluate the effects of body mass index (BMI) change and transition in BMI-metabolic health status on AF.

Methods: We conducted a prospective cohort study within UK Biobank. Metabolic health was defined as having at least four of the six metabolically healthy (MH) criteria including blood pressure, C-reactive protein, triacylglycerols, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glycated hemoglobin.

Results: Among 490,969 participants initially included for baseline BMI analysis, a total of 33,297 AF cases were observed during a median follow-up of 14.0 years. Overweight (hazard ratio [HR] 1.12, 95% confidence interval [CI] 1.09-1.15) and obesity (1.74, 1.68-1.79) significantly increased the risk of AF. A BMI loss of over 2% per year was associated with a lower risk of AF (0.75, 0.57-0.99), especially transitioning from obesity to overweight (0.74, 0.54-1.02), though without statistical significance. Compared with MH-normal weight, the HRs for MH-obesity and metabolic unhealthy (MU)- obesity were 1.74 (1.67-1.81) and 1.76 (1.69-1.83), respectively. The transition from MH-overweight/obesity to MU-overweight/obesity increased the risk of AF (1.35, 0.97-1.88).

Conclusion: BMI decrease of over 2% per year was associated with a lower risk of AF, particularly in those changing from obesity to overweight. The transition from MH-overweight/obesity to MU-overweight/obesity increased the AF risk. Weight management and maintenance of metabolic health should be recommended for primary prevention of AF.

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来源期刊

Heart rhythm 医学-心血管系统

CiteScore

10.50

自引率

5.50%

发文量

1465

审稿时长

24 days

期刊介绍： HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability. HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.