Elucidating the Three-Dimensional Structure of Piracetam through Rotational Spectroscopy.

IF 2.5 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
S Mato, S Municio, J L Alonso, E R Alonso, I León
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引用次数: 0

Abstract

Herein we report on the most stable structures adopted by piracetam, a nootropic drug, in isolated conditions. A chirped pulse Fourier transform microwave spectrometer (CP-FTMW) coupled with a laser ablation source has been employed to explore the broadband rotational spectrum of piracetam in the 6.0-14.0 GHz range. Two conformers have been observed. The most stable conformer of piracetam adopts an exo configuration of the ring and is mainly stabilized through a N-H⋅⋅⋅⋅⋅⋅O=C hydrogen bond between the amide group and the rings' carbonyl oxygen. The second conformer is close in stability and only differs in the endo disposition of the ring. The results show a low interconversion barrier between both conformers.

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来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
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