Technical Note: Discordance Between Point of Care (POCT) BNP and Laboratory-Based NT-proBNP Values at Decision Cut-off in Some Patients - POCT BNP Values Below Cut-off Should be Interpreted with Caution.

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annals of clinical and laboratory science Pub Date : 2025-01-01

Megan Nelson, Kristine Zinn, Mercedes Boyd, Amitava Dasgupta

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引用次数: 0

Abstract

Objective: Both B-type natriuretic peptide (BNP) and NT-pro BNP are markers for heart failure. In our hospital and other institutions, both point of care (POCT) BNP and clinical laboratory-based NT-Pro BNP test are used interchangeably by clinicians. We evaluated any discrepancy between these tests at decision cut-off point.

Method: In a three-month period, in 120 patients, both POCT BNP and NT-proBNP were ordered at the same time and we evaluated these results.

Results: We observed significant discordant results in 14 of these patients where POCT BNP concentrations were normal, but NT-pro BNP concentrations were elevated. Moreover, correlation between POCT BNP and NT-proBNP concentrations was also poor and in some cases NT-proBNP values were 15-fold higher than BNP.

Conclusions: Because of this significant discordance, if both tests are ordered for initial diagnosis, POCT BNP result should be interpreted with caution if below the cut-off. Moreover, if only POCT BNP is ordered it may be normal in some patients with heart failure.

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.