Protective Effect of Jiawei Shuxin Tang on Myocardial Ischemia-Reperfusion in Rats with Qi Deficiency and Blood Stasis and Its Correlation with NRG-1.

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annals of clinical and laboratory science Pub Date : 2025-01-01

Mingming Xu, Shen Wang, Dongming Lin

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引用次数: 0

Abstract

Objective: To investigate the protective effect of Jiawei Shuxin Tang (JWSXT) on myocardial ischemia-reperfusion injury (MIRI) rats with Qi deficiency and blood stasis and its correlation with neuregulin-1 (NRG-1).

Methods: 30 rats were used to establish the model of Qi deficiency and blood stasis, and were randomly divided into control group, MIRI model group, and JWSXT group. The traditional Chinese medicine (TCM) phenotypes, echocardiographic performance, myocardial reperfusion area, myocardial infarction area, HE staining, and NRG-1 content changes of rats in each group were compared one week after treatment.

Results: We found that compared with the model group, rats in the JWSXT group showed increased activity as well as improved tongue texture and lip color (P<0.05); LVEF and LVFS increased in the JWSXT group (P<0.05; P<0.05). The percentage of infarct area and the percentage of myocardial ischemia reperfusion area in the JWSXT group was significantly reduced (P<0.05; P<0.05). Compared with the control group, the remaining NRG-1 content in myocardial tissues of rats in the two groups was decreased (P<0.01), and NRG-1 content in the JWSXT group was increased (P<0.05) compared with the model group.

Conclusions: JWSXT can improve reperfusion injury in rats with Qi deficiency and blood stasis infarction, which correlates with NRG-1.

本刊更多论文

加味舒心汤对气虚血瘀大鼠心肌缺血再灌注的保护作用及其与NRG-1的相关性

目的：探讨加味舒心汤对气虚血瘀型心肌缺血再灌注损伤（MIRI）大鼠的保护作用及其与神经调节蛋白-1 （NRG-1）的相关性。方法：取30只大鼠建立气虚血瘀证模型，随机分为对照组、MIRI模型组和JWSXT组。比较治疗后1周各组大鼠中医表型、超声心动图表现、心肌再灌注面积、心肌梗死面积、HE染色及NRG-1含量变化。结果：我们发现，与模型组比较，JWSXT组大鼠活动增强，舌质和唇色改善（ppppppppp）。结论：JWSXT可改善气虚血瘀梗死大鼠再灌注损伤，其作用机制与NRG-1有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.