Novel Less Toxic, Lymphoid Tissue-Targeted Lipid Nanoparticles Containing a Vitamin B5-Derived Ionizable Lipid for mRNA Vaccine Delivery (Adv. Healthcare Mater. 7/2025)

Abstract

Vitamin B5-Derived Ionizable Lipid

The cover art of article 2403366 by Jae-Hwan Nam, Gyochang Keum, Eun-Kyoung Bang, and co-workers represents the core structure of vitamin B5 using symbolic images of avocado and sunflower seeds alongside its chemical depiction. It illustrates the formation of lipid nanoparticles through synthetic ionizable lipids and other lipids, highlighting their protective, immunetriggering properties, effectiveness in targeting viruses, and demonstrating their safety and preventive potential.