Novel Less Toxic, Lymphoid Tissue-Targeted Lipid Nanoparticles Containing a Vitamin B5-Derived Ionizable Lipid for mRNA Vaccine Delivery (Adv. Healthcare Mater. 7/2025)

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-03-17 DOI:10.1002/adhm.202570043

Soyeon Yoo, Muhammad Faisal, Seo-Hyeon Bae, Kounghwa Youn, Hyo-Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae-Hwan Nam, Gyochang Keum, Eun-Kyoung Bang

引用次数: 0

Abstract

Vitamin B5-Derived Ionizable Lipid

The cover art of article 2403366 by Jae-Hwan Nam, Gyochang Keum, Eun-Kyoung Bang, and co-workers represents the core structure of vitamin B5 using symbolic images of avocado and sunflower seeds alongside its chemical depiction. It illustrates the formation of lipid nanoparticles through synthetic ionizable lipids and other lipids, highlighting their protective, immunetriggering properties, effectiveness in targeting viruses, and demonstrating their safety and preventive potential.

Abstract Image

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新型低毒性，淋巴组织靶向脂质纳米颗粒含有维生素b5衍生的可电离脂质，用于mRNA疫苗递送（Adv. Healthcare Mater. 7/2025）

文章2403366的封面由Jae-Hwan Nam、Gyochang Keum、Eun-Kyoung Bang和同事们创作，他们用牛油果和葵花籽的象征性图像代表了维生素B5的核心结构，以及它的化学描述。它说明了脂质纳米颗粒通过合成电离脂质和其他脂质形成，突出了它们的保护、免疫触发特性、靶向病毒的有效性，并展示了它们的安全性和预防潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.