Lysozyme/Tracheal Antimicrobial Peptide-Based Tissue-Specific Expression Antimicrobial Plasmids Show Broad-Spectrum Antibacterial Activities in the Treatment of Mastitis in Mice (Adv. Biology 3/2025)

Abstract

Non-Antibiotic Therapies for Bacterial Infections

The treatment of bacterial diseases is becoming more and more challenging due to the concern of increasing antibiotic resistance. Yi Yang, Yining Meng, and co-workers have developed lysozyme/tracheal antimicrobial peptide-based tissue-specific expression antimicrobial plasmids, alleviating mastitis in mice with a favorable safety profile. Their work offers promising antibiotic alternatives. More details can be found in article number 2400132.