Changes in the Disease Burden of Depressive Disorders Among Middle-Aged and Older Adults (Aged 45–89) in China Over 30 years: Insights From the Global Burden of Disease Study 2021

IF 3.6 3区医学 Q2 GERIATRICS & GERONTOLOGY

International Journal of Geriatric Psychiatry Pub Date : 2025-03-16 DOI:10.1002/gps.70069

Yu Xiao, Ting-ting Chen, Zhou Zhang, Liang Liu, Na Du

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引用次数: 0

Abstract

Objectives

In China, depressive disorder (DD) among middle-aged and older adults is a significant public health concern. This research utilized the latest Global Burden of Disease Study (GBD) database to evaluate the evolving disease burden of DD in this demographic over the past 3 decades.

Methods

Data on the incidence and disability-adjusted life years (DALY) of DD among people aged 45–89 in China between 1992 and 2021 were collected from the GBD 2021. The age-period-cohort (APC) model was applied to determine the effects of age, period, and cohort on the incidence and DALY rates of DD.

Results

(1) Over the last 30 years, there was a 6.49% increase in the overall age-standardized incidence rate (ASIR) and a 3.99% increase in age-standardized DALY rates (ASDR) for DD among middle-aged and older adults in China, with females consistently exhibiting higher ASIR and ASDR than males. In 2020, COVID-19 significantly increased the ASIR and ASDR of DD in the population, especially in females. (2) The APC analysis revealed an annual net drift of 0.38% in incidence and 0.17% in DALY rate. For both genders, local drifts of incidence were negative for the 45–54 age group and positive for the 55–89 age group; DALY rates showed negative local drifts for the 45–59 age group and positive for the 60–89 age group. (3) Incidence and DALY rates increased with age, displaying a trend of initial decline followed by an increase in period effects, but a trend of initial increase followed by a decrease in cohort effects. Moreover, the impacts of age, period, and cohort exhibited gender differences.

Conclusions

Our findings provide a comprehensive and in-depth perspective for studying the changing trends of DD’s burden in China and for identifying targeted prevention and treatment policies for DD from different aspects.

查看原文本刊更多论文

30岁以上中国中老年人（45-89岁）抑郁症疾病负担的变化：来自2021年全球疾病负担研究的见解

在中国，中老年人群中的抑郁症（DD）是一个重要的公共卫生问题。本研究利用最新的全球疾病负担研究（GBD）数据库来评估过去30年来该人群中DD疾病负担的演变。方法收集1992 - 2021年中国45-89岁人群DD发病率和残疾调整生命年（DALY）数据。应用年龄-时期-队列（APC）模型确定年龄、时期和队列对DD发病率和DALY率的影响。结果(1)在过去30年中，中国中老年DD的总年龄标准化发病率（ASIR）增加了6.49%，年龄标准化DALY率（ASDR）增加了3.99%；女性表现出的ASIR和ASDR始终高于男性。2020年，COVID-19显著增加了人群，特别是女性中DD的ASIR和ASDR。(2) APC分析显示，年净漂移率为0.38%，DALY率为0.17%。无论男女，45-54岁年龄组发病率的局部漂移为负，55-89岁年龄组发病率的局部漂移为正；45-59岁年龄组的DALY率为负，60-89岁年龄组为正。(3)发病率和DALY率随年龄增长呈先下降后时期效应增加的趋势，而队列效应呈先上升后下降的趋势。此外，年龄、时期和队列的影响表现出性别差异。结论本研究结果为研究中国DD负担变化趋势，从不同角度制定有针对性的DD防治政策提供了全面、深入的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Geriatric Psychiatry 医学-精神病学

CiteScore

6.10

自引率

2.50%

发文量

168

审稿时长

4-8 weeks

期刊介绍： The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers. The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.