Sensitizations to pollen differ between Central European and Sub-Saharan African atopic dermatitis patients

Q3 Medicine

Allergo Journal International Pub Date : 2024-10-21 DOI:10.1007/s40629-024-00313-9

Danielle Fehr, Muriel Rentschler, Fandresena Sendrasoa, Nick Li, Anna White, Meike Distler, Claudia Lang, Gloria Masenga, Nelson Mosha, George Semango, Clara Clemens, Tahinamandranto Rasamoelina, Abel Hermann Soankasina, Fahafahantsoa Rapelanoro Rabenja, Daudi Mavura, John Elisante Masenga, Peter Schmid-Grendelmeier, Marie-Charlotte Brüggen MD PhD

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引用次数: 0

Abstract

Atopic dermatitis (AD) is often associated with allergic comorbidities, such as allergic asthma or allergic rhinoconjunctivitis (ARC). Sensitizations to pollen can directly impact AD, as patients can experience exacerbation during pollen season. This study aims to gain more insights into the pollen sensitization patterns of AD patients in Central Europe compared with sub-Saharan Africa (SSA).

We performed a case–control study involving a total of 90 participants: 20 AD patients and 10 healthy controls (HC) each from Switzerland (CH), Tanzania (TZ), and Madagascar (MD). We collected clinical data and serum samples and performed a multiplex IgE test (ALEX² Allergy Explorer, MacroArray Diagnostics, Vienna, Austria).

The prevalence of ARC and asthma in AD patients was similar in all countries (ARC: 60% TZ, 70% CH, 75% MD; asthma: 25% TZ, 30% CH, 20% MD). Total IgE levels were significantly higher in both SSA HC populations compared with the Swiss HC. The analysis of specific IgE levels revealed major differences in sensitization patterns between Africa and Europe, especially regarding grass pollen allergens. Swiss AD patients were sensitized to various grass pollen such as Bahia grass, Bermuda grass, common reed, perennial ryegrass, rye, and timothy grass. However, these allergens were irrelevant in the SSA population: no AD patient or HC subject was sensitized to the tested grass pollen.

The considerably different sensitization patterns between European and SSA AD patients warrant the development of allergy testing and desensitization therapies tailored to the African setting. Therefore, there is a need to characterize local pollen types and counts.

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中欧和撒哈拉以南非洲的特应性皮炎患者对花粉的敏感性不同

特应性皮炎（AD）通常伴有过敏性合并症，如过敏性哮喘或过敏性鼻结膜炎（ARC）。对花粉过敏会直接影响特应性皮炎，因为患者会在花粉季节病情加重。我们进行了一项病例对照研究，共有 90 人参与：分别来自瑞士（CH）、坦桑尼亚（TZ）和马达加斯加（MD）的 20 名 AD 患者和 10 名健康对照（HC）。我们收集了临床数据和血清样本，并进行了多重 IgE 检测（ALEX2 Allergy Explorer，MacroArray Diagnostics，奥地利维也纳）。所有国家的 AD 患者的 ARC 和哮喘发病率相似（ARC：60% TZ、70% CH、75% MD；哮喘：25% TZ、30% CH、20% MD）。与瑞士高危人群相比，SSA 和瑞士高危人群的总 IgE 水平明显较高。对特异性 IgE 水平的分析表明，非洲和欧洲的致敏模式存在很大差异，尤其是在草花粉过敏原方面。瑞士 AD 患者对多种草花粉过敏，如巴伊亚草、百慕大草、普通芦苇、多年生黑麦草、黑麦和梯牧草。欧洲和非洲撒哈拉以南地区 AD 患者的致敏模式大相径庭，因此需要开发适合非洲环境的过敏测试和脱敏疗法。因此，有必要确定当地的花粉类型和数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergo Journal International Medicine-Immunology and Allergy

CiteScore

4.60

自引率

0.00%

发文量

期刊介绍： Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.