Analysis of the effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2025-03-17 DOI:10.1007/s00403-025-04087-0

Xiaoping Zhang, Lu Wang, Fumin Fang

{"title":"Analysis of the effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria","authors":"Xiaoping Zhang, Lu Wang, Fumin Fang","doi":"10.1007/s00403-025-04087-0","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria(CU) was examined.</p><h3>Methods</h3><p>100 patients with CU were divided into an observation group (treatment with levocetirizine hydrochloride dispersible tablets) and a control group (conventional treatment).</p><h3>Results</h3><p>The total effective rate and incidence of adverse reactions in the control group were lower than those in the observation group. Following a four-week course of therapy, the observation group’s levels of serotonin (5-HT), interleukin-4 (IL-4), and interleukin-17 (IL-17) were all greater. Both the UAS and DLQI scores were much lower than they were prior to therapy, and the observation group’s scores were considerably lower. The relief time of symptoms such as skin itching, redness, tingling, and fever in the observation group was shorter; suggesting that the therapy of persistent urticaria with dispersible tablets containing levocetirizine hydrochloride is viable.</p><h3>Conclusion</h3><p>When levocetirizine hydrochloride dispersible tablets are used to treat CU, the patient’s inflammatory response is decreased, inflammatory factors 5-HT, IL-4, and IL-17 levels are improved, the associated symptoms are encouraged to resolve, adverse responses are prevented, and a better prognosis is provided.</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00403-025-04087-0.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Dermatological Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00403-025-04087-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

Effect of levocetirizine hydrochloride dispersible tablets on inflammatory factors in the treatment of chronic urticaria(CU) was examined.

Methods

100 patients with CU were divided into an observation group (treatment with levocetirizine hydrochloride dispersible tablets) and a control group (conventional treatment).

Results

The total effective rate and incidence of adverse reactions in the control group were lower than those in the observation group. Following a four-week course of therapy, the observation group’s levels of serotonin (5-HT), interleukin-4 (IL-4), and interleukin-17 (IL-17) were all greater. Both the UAS and DLQI scores were much lower than they were prior to therapy, and the observation group’s scores were considerably lower. The relief time of symptoms such as skin itching, redness, tingling, and fever in the observation group was shorter; suggesting that the therapy of persistent urticaria with dispersible tablets containing levocetirizine hydrochloride is viable.

Conclusion

When levocetirizine hydrochloride dispersible tablets are used to treat CU, the patient’s inflammatory response is decreased, inflammatory factors 5-HT, IL-4, and IL-17 levels are improved, the associated symptoms are encouraged to resolve, adverse responses are prevented, and a better prognosis is provided.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.