Interplay of transposable elements and ageing: epigenetic regulation and potential epitranscriptomic influence

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2025-03-17 DOI:10.1016/j.gde.2025.102331

Raquel García-Vílchez, Diana Guallar

引用次数: 0

Abstract

Transposable elements (TEs) are mobile elements, which have been crucial for mammalian genome evolution and function. Their activity, which influences genomic stability, gene expression and chromatin state, is tightly regulated by complex mechanisms. This review examines recent findings on TE regulation and the dynamics and connection during the ageing process. Here, we explore the interplay between chromatin state, DNA, RNA, and histone modifications in controlling TE activity, with a special emphasis in elucidating the emerging role of epitranscriptomic modifications in TE regulation. Additionally, we analyse the connection between TE activation and ageing, with the perspective for future research that could reveal novel targets for alleviating physiological and pathological ageing and age-related diseases.

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转座因子与衰老的相互作用：表观遗传调控和潜在的表转录组影响

转座因子（te）是一种可移动因子，在哺乳动物基因组进化和功能中起着至关重要的作用。它们的活性受到复杂机制的严格调控，影响着基因组的稳定性、基因表达和染色质状态。这篇综述探讨了TE调控和衰老过程中动态和联系的最新发现。在这里，我们探讨了染色质状态、DNA、RNA和组蛋白修饰在控制TE活性中的相互作用，特别强调了表观转录组修饰在TE调控中的新作用。此外，我们分析了TE激活与衰老之间的联系，以期为未来的研究揭示缓解生理和病理衰老以及年龄相关疾病的新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)